Detection of tetraploidization in chromophobe renal cell carcinoma: Insights and pitfalls
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DOI: 10.1002/gcc.22886
Abstract: Chromosomal losses resulting in a marked hypodiploidy are a specificity of chromophobe renal cell carcinoma (ChRCC), the third most frequent type of kidney cancer. Its detection is useful in challenging cases. However some ChRCC, especially… read more here.
Keywords: array; renal cell; chromosomal losses; cell carcinoma ... See more keywords
Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma.
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DOI: 10.1016/j.ccell.2018.06.013
Abstract: Hürthle cell carcinoma of the thyroid (HCC) is a form of thyroid cancer recalcitrant to radioiodine therapy that exhibits an accumulation of mitochondria. We performed whole-exome sequencing on a cohort of primary, recurrent, and metastatic… read more here.
Keywords: chromosomal losses; widespread chromosomal; cell carcinoma; cell ... See more keywords
Unique landscape of widespread chromosomal losses in Hürthle cell carcinoma.
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DOI: 10.1530/erc-18-0481
Abstract: In their back-to-back published articles "Integrated Genomic Analysis of Hürthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes" and "Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle… read more here.
Keywords: chromosomal losses; widespread chromosomal; cell carcinoma; cell ... See more keywords