Advances in chromosomal translocations and fusion genes in sarcomas and potential therapeutic applications.
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DOI: 10.1016/j.ctrv.2017.12.001
Abstract: Chromosomal translocations and fusion genes are very common in human cancer especially in subtypes of sarcomas, such as rhabdomyosarcoma, Ewing's sarcoma, synovial sarcoma and liposarcoma. The discovery of novel chromosomal translocations and fusion genes in… read more here.
Keywords: translocations fusion; genes sarcomas; chromosomal translocations; advances chromosomal ... See more keywords
Absence of chromosomal translocations and protein expression of ALK in sinonasal adenocarcinomas.
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DOI: 10.1016/j.otorri.2016.02.003
Abstract: INTRODUCTION Chromosomal translocations at 2p23 cause overexpression of anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase involved in signalling pathways that regulate cell proliferation. This translocation occurs in 5% of lung adenocarcinoma and has been… read more here.
Keywords: protein expression; chromosomal translocations; sinonasal adenocarcinomas; alk ... See more keywords
Chromosomal translocations and semen quality: A study on 144 male translocation carriers.
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DOI: 10.1016/j.rbmo.2018.10.003
Abstract: RESEARCH QUESTION Chromosomal translocations are known genetic causes of male infertility. Are certain translocations or chromosomal regions more directly associated with sperm defects? Is there a threshold of sperm impairment that can be relevant for… read more here.
Keywords: semen quality; chromosomal translocations; nps asp; study ... See more keywords
Generation of chromosomal translocations that lead to conditional fusion protein expression using CRISPR-Cas9 and homology-directed repair.
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DOI: 10.1016/j.ymeth.2017.05.006
Abstract: Recurrent chromosomal translocations often lead to expression of fusion proteins associated with oncogenic transformation. To study translocations and downstream events, genome editing techniques have been developed to generate chromosomal translocations through non-homologous end joining of… read more here.
Keywords: directed repair; chromosomal translocations; crispr cas9; homology directed ... See more keywords
Nonamer dependent RAG cleavage at CpGs can explain mechanism of chromosomal translocations associated to lymphoid cancers
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DOI: 10.1371/journal.pgen.1010421
Abstract: Chromosomal translocations are considered as one of the major causes of lymphoid cancers. RAG complex, which is responsible for V(D)J recombination, can also cleave non-B DNA structures and cryptic RSSs in the genome leading to… read more here.
Keywords: lymphoid cancers; cleavage; chromosomal translocations; cpgs ... See more keywords
Factors That Affect the Formation of Chromosomal Translocations in Cells
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DOI: 10.3390/cancers14205110
Abstract: Simple Summary Chromosomal translocations are products of the erroneous repair of DNA double-strand breaks that result in the illegitimate joining of the two broken chromosomal ends from non-homologous chromosomes. Chromosomal translocations have been linked to… read more here.
Keywords: factors affect; translocations cells; chromosomal translocations; affect formation ... See more keywords