Abstract A030: Discovery and preclinical characterization of novel macrocyclic KIF18A Inhibitors for treatment of chromosomally instable tumors
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DOI: 10.1158/1535-7163.targ-25-a030
Abstract: Chromosome instability (CIN) and Genetic instability are hallmark features of malignant tumor cells, contributing to tumour progression, drug resistance and metastasis. KIF18A, a member of the kinesin superfamily of motor proteins, is essential for preserving… read more here.
Keywords: kif18a inhibitors; novel macrocyclic; macrocyclic kif18a; chromosomally instable ... See more keywords