Mlh1 deficiency in normal mouse colon mucosa associates with chromosomally unstable colon cancer
Sign Up to like & getrecommendations! Published in 2018 at "Carcinogenesis"
DOI: 10.1093/carcin/bgy056
Abstract: Abstract Colorectal cancer (CRC) genome is unstable and different types of instabilities, such as chromosomal instability (CIN) and microsatellite instability (MSI) are thought to reflect distinct cancer initiating mechanisms. Although 85% of sporadic CRC reveal… read more here.
Keywords: colon; chromosomally unstable; expression; cancer ... See more keywords
Abstract 517: Targeting chromosomally unstable tumors with a selective KIF18A inhibitor
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-517
Abstract: Chromosome instability (CIN) is an attribute of cancer cells that has yet to be fully exploited therapeutically, despite its prevalence across many tumor types and lack of occurrence in normal cells. To identify genes uniquely… read more here.
Keywords: selective kif18a; kif18a inhibitor; kif18a; tumor ... See more keywords