How chromosome topologies get their shape: views from proximity ligation and microscopy methods
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13961
Abstract: The 3D organization of our genome is an important determinant for the transcriptional output of a gene in (patho)physiological contexts. The spatial organization of linear chromosomes within nucleus is dominantly inferred using two distinct approaches,… read more here.
Keywords: proximity ligation; microscopy; ligation; dna fish ... See more keywords
An approach on the migratory processes in the north of Chile based on Y chromosome analysis
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Human Biology"
DOI: 10.1002/ajhb.23736
Abstract: Northern Chile is an area characterized by a complex cultural and demographic trajectory. During the last few centuries, this complex trajectory has become the destination of intra‐ and intercontinental migratory waves. In this study, we… read more here.
Keywords: migratory; migratory processes; north chile; processes north ... See more keywords
Common X‐Chromosome Variants Are Associated with Parkinson Disease Risk
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DOI: 10.1002/ana.26051
Abstract: The objective of this study was to identify genetic variants on the X‐chromosome associated with Parkinson disease (PD) risk. read more here.
Keywords: associated parkinson; chromosome; disease risk; parkinson disease ... See more keywords
Applying iPSCs for Preserving Endangered Species and Elucidating the Evolution of Mammalian Sex Determination
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DOI: 10.1002/bies.201700152
Abstract: The endangered species Tokudaia osimensis has the unique chromosome constitution of 2n = 25, with an XO/XO sex chromosome configuration (2n = 25; XO). There is urgency to preserve this species and to elucidate the regulator(s) that can discriminate… read more here.
Keywords: endangered species; determination; sex determination; applying ipscs ... See more keywords
iPSCs from an Endangered Mammalian Species Could Elucidate the Mechanism of Sex Determination with Evolutionary Y Chromosome Loss
Sign Up to like & getrecommendations! Published in 2018 at "BioEssays"
DOI: 10.1002/bies.201800059
Abstract: Since the successful derivation of induced pluripotent stem cells (iPSCs) in 2006, this strategy has been used to make what was once fantasy into reality. In this issue of BioEssays, Honda proposes using iPSCs for… read more here.
Keywords: mechanism; ipscs endangered; sex; osimensis ... See more keywords
Karyotype variation of CHO host cell lines over time in culture characterized by chromosome counting and chromosome painting
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26453
Abstract: Genomic rearrangements are a common phenomenon in rapidly growing cell lines such as Chinese hamster ovary (CHO) cells, a feature that in the context of production of biologics may lead to cell line and product… read more here.
Keywords: cell lines; time; cho; cell ... See more keywords
Artificial induction of chromosome aneuploidy in CHO cells alters their function as host cells
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28289
Abstract: Chinese hamster ovary (CHO) cells are major host cells for biopharmaceuticals. During culture, the chromosome number of CHO cells alters spontaneously. Here, we investigated the effects of artificial changes in the chromosome number on productivity.… read more here.
Keywords: host; chromosome; cho cells; chromosome number ... See more keywords
The prognostic significance of chromosome 17 abnormalities in patients with myelodysplastic syndrome treated with 5‐azacytidine: Results from the Hellenic 5‐azacytidine registry
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2090
Abstract: In patients with myelodysplastic syndrome (MDS), the prognostic significance of chromosome 17 abnormalities has not yet been fully elucidated, except for isochromosome 17q that has been characterized as an intermediate risk abnormality in the Revised… read more here.
Keywords: chromosome abnormalities; significance chromosome; abnormality; chromosome ... See more keywords
Establishment and characterization of a novel Hodgkin lymphoma cell line, AM‐HLH, carrying the Epstein‐Barr virus genome integrated into the host chromosome
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2369
Abstract: We describe the establishment and characterization of a cell line, AM‐HLH, obtained from a patient with Epstein‐Barr virus–positive (EBV+) nodular sclerosis–type Hodgkin lymphoma (HL). The cells were positive for CD2 and CD30 and negative for… read more here.
Keywords: establishment characterization; cell line; chromosome; hlh ... See more keywords
An improved deep convolutional neural network architecture for chromosome abnormality detection using hybrid optimization model
Sign Up to like & getrecommendations! Published in 2022 at "Microscopy Research and Technique"
DOI: 10.1002/jemt.24170
Abstract: Chromosomes are thread‐like structures located in the cell nucleus that contains the human body blueprint. Chromosome analysis is also known as karyotyping is the test taken to detect the abnormalities identified in the human chromosome.… read more here.
Keywords: methodology; dcnn architecture; deep convolutional; chromosome ... See more keywords
Insight into magnesium ions effect on chromosome banding and ultrastructure
Sign Up to like & getrecommendations! Published in 2022 at "Microscopy Research and Technique"
DOI: 10.1002/jemt.24190
Abstract: Magnesium ion (Mg2+) plays a fundamental role in chromosome condensation which is important for genetic material segregation. Studies about the effects of Mg2+ on the overall chromosome structure have been reported. Nevertheless, its effects on… read more here.
Keywords: magnesium; mg2; chromosome; chromosomes treated ... See more keywords