G1 Premature Chromosome Condensation (PCC) Assay.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9432-8_4
Abstract: Premature chromosome condensation (PCC) is a sensitive and unique way to detect interphase chromosome damage and its recovery in mammalian cells irradiated with ionizing radiation. In this chapter, we describe G1 PCC assay with which… read more here.
Keywords: premature chromosome; chromosome condensation; pcc assay; condensation pcc ... See more keywords
Refined premature chromosome condensation (G0-PCC) with cryo-preserved mitotic cells for rapid radiation biodosimetry
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92886-6
Abstract: Mitotic cell fusion induced Premature Chromosome Condensation (G0-PCC) assay in human lymphocytes allows rapid detection of cytogenetic damage in interphase stage, within few hours after blood collection. Hence, it is the most suitable method for… read more here.
Keywords: pcc; mitotic cells; chromosome condensation; cryo preserved ... See more keywords
Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2210593120
Abstract: Significance During the interphase of the cell cycle, chromatin is accessible to the transcription machinery, which allows gene expression. When cells enter mitosis, chromosomes strongly condense, which facilitates their symmetrical segregation at the end of… read more here.
Keywords: condensation; chromosome condensation; gene expression; mitotic chromosome ... See more keywords
Mitotic chromosome condensation requires phosphorylation of the centromeric protein KNL-2 in C. elegans.
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DOI: 10.1242/jcs.259088
Abstract: Centromeres are chromosomal regions that serve as sites for kinetochore formation and microtubule attachment, processes that are essential for chromosome segregation during mitosis. Centromeres are almost universally defined by the histone variant CENP-A. In the… read more here.
Keywords: chromosome condensation; knl; cenp; phosphorylation ... See more keywords
Detecting Chromosome Condensation Defects in Gulf War Illness Patients
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DOI: 10.2174/1389202918666170705150819
Abstract: Background: Gulf War Illness (GWI) impacts 25-30% of gulf war veterans. Due to its heterogeneity in both etiology and symptoms, it has been challenging to establish the commonly accepted case definition for GWI. Equally challenging… read more here.
Keywords: gulf war; gwi patients; condensation; chromosome condensation ... See more keywords
Regulator of Chromosome Condensation 2 Modulates Cell Cycle Progression, Tumorigenesis, and Therapeutic Resistance
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2020.620973
Abstract: Accurate regulation of cell cycle is important for normal tissue development and homeostasis. RCC2 (Regulator of Chromosome Condensation 2) play a role as chromosomal passenger complex (CPC) implicated in all cell cycle phases. RCC2 was… read more here.
Keywords: therapeutic resistance; cell cycle; cycle; regulator chromosome ... See more keywords