Exploring the significance of PAK1 through chromosome conformation signatures in ibrutinib‐resistant chronic lymphocytic leukaemia
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13281
Abstract: Ibrutinib exerts promising anticancer effects in chronic lymphocytic leukaemia (CLL). However, acquired resistance occurs during treatment, necessitating the exploration of underlying mechanisms. Although three‐dimensional genome organization has been identified as a major player in the… read more here.
Keywords: pak1; ibrutinib resistant; chronic lymphocytic; chromosome conformation ... See more keywords
Detecting Long-Range Enhancer-Promoter Interactions by Quantitative Chromosome Conformation Capture.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-4035-6_6
Abstract: Chromosome conformation capture (3C) technology and its derivatives are currently the primary methodologies measuring contacts among genomic elements. In fact, the lion share of what is currently known about chromosome folding is based on 3C-related… read more here.
Keywords: detecting long; chromosome; chromosome conformation; conformation capture ... See more keywords
Technical Review: A Hitchhiker's Guide to Chromosome Conformation Capture.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7318-7_14
Abstract: The introduction of chromosome conformation capture (3C) technologies boosted the field of 3D-genome research and significantly enhanced the available toolset to study chromosomal architecture. 3C technologies not only offer increased resolution compared to the previously… read more here.
Keywords: technical review; chromosome conformation; conformation capture;
Hi-C 2.0: An optimized Hi-C procedure for high-resolution genome-wide mapping of chromosome conformation.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2017.04.004
Abstract: Chromosome conformation capture-based methods such as Hi-C have become mainstream techniques for the study of the 3D organization of genomes. These methods convert chromatin interactions reflecting topological chromatin structures into digital information (counts of pair-wise… read more here.
Keywords: optimized procedure; resolution; high resolution; chromosome conformation ... See more keywords
A chromosome conformation capture ordered sequence of the barley genome.
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature22043
Abstract: Cereal grasses of the Triticeae tribe have been the major food source in temperate regions since the dawn of agriculture. Their large genomes are characterized by a high content of repetitive elements and large pericentromeric… read more here.
Keywords: sequence; barley; chromosome conformation; conformation capture ... See more keywords
Identification of a novel distal regulatory element of the human Neuroglobin gene by the chromosome conformation capture approach
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw820
Abstract: Neuroglobin (NGB) is predominantly expressed in the brain and retina. Studies suggest that NGB exerts protective effects to neuronal cells and is implicated in reducing the severity of stroke and Alzheimer's disease. However, little is… read more here.
Keywords: expression; gene; gene chromosome; distal regulatory ... See more keywords
Improving and correcting the contiguity of long-read genome assemblies of three plant species using optical mapping and chromosome conformation capture data.
Sign Up to like & getrecommendations! Published in 2017 at "Genome research"
DOI: 10.1101/gr.213652.116
Abstract: Long-read sequencing can overcome the weaknesses of short reads in the assembly of eukaryotic genomes; however, at present additional scaffolding is needed to achieve chromosome-level assemblies. We generated Pacific Biosciences (PacBio) long-read data of the… read more here.
Keywords: chromosome conformation; chromosome; optical mapping; conformation capture ... See more keywords
Improved inference of chromosome conformation from images of labeled loci.
Sign Up to like & getrecommendations! Published in 2018 at "F1000Research"
DOI: 10.12688/f1000research.16252.2
Abstract: We previously published a method that infers chromosome conformation from images of fluorescently-tagged genomic loci, for the case when there are many loci labeled with each distinguishable color. Here we build on our previous work… read more here.
Keywords: labeled loci; improved inference; conformation images; chromosome conformation ... See more keywords
Major Reorganization of Chromosome Conformation During Muscle Development in Pig
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.748239
Abstract: The spatial organization of the genome in the nucleus plays a crucial role in eukaryotic cell functions, yet little is known about chromatin structure variations during late fetal development in mammals. We performed in situ… read more here.
Keywords: conformation muscle; conformation; muscle development; development ... See more keywords
Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1129207
Abstract: Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis of the spine exhibiting a strong genetic background. The mechanistic and functional understanding of the AS-associated genomic loci, identified with Genome Wide Association Studies (GWAS), remains challenging.… read more here.
Keywords: chromosome conformation; ankylosing spondylitis; conformation; conformation capture ... See more keywords