MKLP2 functions in early mitosis to ensure proper chromosome congression.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.259560
Abstract: Mitotic kinesin-like protein 2 (MKLP2) is a motor protein with a well-established function in promoting cytokinesis. However, our results with siRNAs targeting MKLP2 and small molecule inhibitors of MKLP2 (MKLP2i) suggested a function earlier in… read more here.
Keywords: mklp2 functions; mklp2; chromosome congression; mitosis ... See more keywords
BUB-1 targets PP2A:B56 to regulate chromosome congression during meiosis I in C. elegans oocytes
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DOI: 10.7554/elife.65307
Abstract: Protein Phosphatase 2A (PP2A) is a heterotrimer composed of scaffolding (A), catalytic (C), and regulatory (B) subunits. PP2A complexes with B56 subunits are targeted by Shugoshin and BUBR1 to protect centromeric cohesion and stabilise kinetochore–microtubule… read more here.
Keywords: meiosis; pp2a b56; chromosome congression; congression meiosis ... See more keywords