Chromosome contacts in activated T cells identify autoimmune disease candidate genes
Sign Up to like & getrecommendations! Published in 2017 at "Genome Biology"
DOI: 10.1186/s13059-017-1285-0
Abstract: BackgroundAutoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4+ T cells. Linking such regulatory regions to gene promoters in disease-relevant cell contexts facilitates identification of candidate disease genes.ResultsWithin 4 h, activation… read more here.
Keywords: candidate; disease; contacts activated; activated cells ... See more keywords
Meiotic Chromosome Contacts as a Plausible Prelude for Robertsonian Translocations
Sign Up to like & getrecommendations! Published in 2020 at "Genes"
DOI: 10.3390/genes11040386
Abstract: Robertsonian translocations are common chromosomal alterations. Chromosome variability affects human health and natural evolution. Despite the significance of such mutations, no mechanisms explaining the emergence of such translocations have yet been demonstrated. Several models have… read more here.
Keywords: meiotic chromosome; homologous chromosomes; contacts plausible; robertsonian translocations ... See more keywords