X-Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA Methylation Levels
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DOI: 10.1016/j.stemcr.2018.12.004
Abstract: Summary Reprogramming female mouse somatic cells into induced pluripotent stem cells (iPSCs) leads to X-chromosome reactivation. The extent to which increased X-chromosome dosage (X-dosage) in female iPSCs compared with male iPSCs leads to differences in… read more here.
Keywords: dosage modulates; pluripotent stem; chromosome dosage; dosage ... See more keywords
Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation
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DOI: 10.1038/s41556-020-00607-4
Abstract: X-chromosome dosage compensation in female placental mammals is achieved by X-chromosome inactivation (XCI). An exception are human pre-implantation embryos, where dosage compensation occurs by X-chromosome dampening (XCD). Here, we examined whether XCD extends to human… read more here.
Keywords: dosage compensation; germ cells; dosage; chromosome dosage ... See more keywords