Chromosome organization in bacteria: mechanistic insights into genome structure and function
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DOI: 10.1038/s41576-019-0185-4
Abstract: Bacterial chromosomes are folded to compact DNA and facilitate cellular processes. Studying model bacteria has revealed aspects of chromosome folding that are applicable to many species. Primarily controlled by nucleoid-associated proteins, chromosome folding is hierarchical,… read more here.
Keywords: associated proteins; chromosome folding; chromosome structure; nucleoid associated ... See more keywords
Regulation of the mitotic chromosome folding machines
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DOI: 10.1042/bcj20210140
Abstract: Over the last several years enormous progress has been made in identifying the molecular machines, including condensins and topoisomerases that fold mitotic chromosomes. The discovery that condensins generate chromatin loops through loop extrusion has revolutionized,… read more here.
Keywords: regulation mitotic; folding machines; chromosome folding; chromosome ... See more keywords
Regulation of cohesinâmediated chromosome folding by PDS5 in mammals
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DOI: 10.15252/embr.202254853
Abstract: Cohesin regulates sister chromatid cohesion but also contributes to chromosome folding by promoting the formation of chromatin loops, a process mediated by loop extrusion. Although PDS5 regulates cohesin dynamics on chromatin, the exact function of… read more here.
Keywords: cohesin; pds5a pds5b; chromosome folding; cohesin mediated ... See more keywords