Single-chromosome Gains Commonly Function as Tumor Suppressors.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2016.12.004
Abstract: Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here, we investigated the relationship between aneuploidy and cancer development using cells engineered to harbor single extra chromosomes. We found that nearly… read more here.
Keywords: commonly function; single chromosome; chromosome gains; function tumor ... See more keywords
Singling Out Chromosome Gains in Tumor Evolution.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.01.011
Abstract: In this issue of Cancer Cell, Sheltzer et al. shed new light on Theodor Boveri's century-old hypothesis by demonstrating that aneuploidy characterized by single-chromosome gains acts to suppress tumorigenesis and that aneuploidy itself is a nidus… read more here.
Keywords: singling chromosome; gains tumor; chromosome gains; tumor evolution ... See more keywords