Chromosome instability syndromes
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Disease Primers"
DOI: 10.1038/s41572-019-0123-y
Abstract: Fanconi anaemia, ataxia telangiectasia, Nijmegen breakage syndrome and Bloom syndrome are rare, clinically distinct, chromosome instability disorders that predispose to cancer. This PrimeView highlights the clinical features of these disorders, which are clinically distinct and… read more here.
Keywords: instability syndromes; instability; chromosome instability;
Heparanase Is a Critical Regulator of Mitotic Spindles Required for Maintaining Chromosome Stability.
Sign Up to like & getrecommendations! Published in 2018 at "DNA and cell biology"
DOI: 10.1089/dna.2017.3990
Abstract: The mitotic spindle, assembled by microtubule organization center (MTOC), is a critical structure required for proper chromosome segregation during mitosis. Studies demonstrated that defects of mitotic spindle assembling would result in chromosome instability, associating with… read more here.
Keywords: hpse; chromosome instability; heparanase critical; mitotic spindle ... See more keywords
MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-17-0909
Abstract: ADP-ribosylation is an important posttranslational protein modification that regulates diverse biological processes, controlled by dedicated transferases and hydrolases. Here, we show that frequent deletions (∼30%) of the MACROD2 mono-ADP-ribosylhydrolase locus in human colorectal cancer cause… read more here.
Keywords: cancer; activity; macrod2 haploinsufficiency; chromosome instability ... See more keywords
Novel assay to measure chromosome instability identifies Punica granatum extract that elevates CIN and has a potential for tumor- suppressing therapies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.989932
Abstract: Human artificial chromosomes (HACs) have provided a useful tool to study kinetochore structure and function, gene delivery, and gene expression. The HAC propagates and segregates properly in the cells. Recently, we have developed an experimental… read more here.
Keywords: extract; chromosome instability; hac; cin ... See more keywords
Chromosome instability in neuroblastoma: A pathway to aggressive disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.988972
Abstract: For over 100-years, genomic instability has been investigated as a central player in the pathogenesis of human cancer. Conceptually, genomic instability includes an array of alterations from small deletions/insertions to whole chromosome alterations, referred to… read more here.
Keywords: chromosome instability; instability; chromosome; chromosome aneuploidy ... See more keywords
HIV Infection, Chromosome Instability, and Micronucleus Formation
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15010155
Abstract: Genome integrity is critical for proper cell functioning, and chromosome instability can lead to age-related diseases, including cancer and neurodegenerative disorders. Chromosome instability is caused by multiple factors, including replication stress, chromosome missegregation, exposure to… read more here.
Keywords: chromosome instability; instability; hiv infection;