Monosomy of Chromosome 9 Is Associated With Higher Grade, Advanced Stage, and Adverse Outcome in Clear-cell Renal Cell Carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical genitourinary cancer"
DOI: 10.1016/j.clgc.2019.09.016
Abstract: BACKGROUND Clear-cell renal cell carcinoma (ccRCC) is one of the most common malignancies in humans and is usually associated with poor outcomes. Cancers are considered to be genetic diseases. Therefore, a better understanding of genetic… read more here.
Keywords: chromosome loss; cell renal; cell; clear cell ... See more keywords
BIOM-08. CHROMOSOME 1P LOSS AND 1Q GAIN ARE HIGHLY PROGNOSTIC AND CAN INFORM WHO GRADING OF MENINGIOMA
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.0096
Abstract: The CNS WHO grade of meningioma was updated in 2021 to include rare molecular features, namely homozygous deletions of CDKN2A or CDKN2B and TERT promotor mutations. Previous work including the cIMPACT-NOW update 8 have discussed… read more here.
Keywords: loss; gain; chromosome loss; chromosome ... See more keywords
PATH-48. Molecularly defined glioblastoma with combined gain of chromosome 7 and loss of chromosome 10 presenting microscopically as a low-grade, benign, multi nodular vacuolating tumor
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.1000
Abstract: We report a case of a 38-year-old German male, without co-morbidities or previous hospitalization, who presented with new onset seizures. Cranial MRI revealed three ill-defined lesions with no contrast enhancement on the left frontal lobe,… read more here.
Keywords: grade; gain chromosome; chromosome loss; tumor ... See more keywords
Identification of multiomics map and key biomarkers in uveal melanoma with chromosome 3 loss
Sign Up to like & getrecommendations! Published in 2024 at "Annals of Medicine and Surgery"
DOI: 10.1097/ms9.0000000000001585
Abstract: Purpose: Chromosome 3 loss is an independent risk factor for uveal melanoma (UM), but its exact molecular mechanisms remain unclear. This study was designed to investigate the relationship between chromosome 3 loss and molecular alterations… read more here.
Keywords: uveal melanoma; loss; analysis; chromosome loss ... See more keywords
Dissociation of the nuclear basket triggers chromosome loss in aging yeast
Sign Up to like & getrecommendations! Published in 2025 at "eLife"
DOI: 10.1101/2024.10.31.621394
Abstract: In many organisms, aging is a clear risk factor for chromosome mis-segregation, the main source of aneuploidy. Here, we report that old yeast cells lose chromosomes by partitioning them asymmetrically to their daughter cells together… read more here.
Keywords: chromosome loss; basket; dissociation nuclear; nuclear basket ... See more keywords
Y Chromosome Loss and Implications for Oncology
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-24-0105
Abstract: The Y chromosome has recognized functions in promoting male sex determination and regulating aspects of fertility. However, recent work has demonstrated important roles for the Y chromosome and Y-encoded genes in multiple domains of male… read more here.
Keywords: oncology; encoded genes; cancer; chromosome loss ... See more keywords
Abstract IA005: Y chromosome loss in cancer drives growth by evasion of adaptive immunity
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.bladder24-ia005
Abstract: Loss of the Y chromosome (LOY) is observed in 10-40% of bladder cancers, but its clinical and biological significance is unknown. We will present genomic and transcriptomic studies that show LOY correlates with poor prognoses… read more here.
Keywords: cancer; loss cancer; chromosome loss; chromosome ... See more keywords
Quantifying Y chromosome loss in primary and metastatic prostate cancer by chromosome painting.
Sign Up to like & getrecommendations! Published in 2024 at "PloS one"
DOI: 10.1371/journal.pone.0301989
Abstract: Somatic Y chromosome loss in hematopoietic cells is associated with higher mortality in men. However, the status of the Y chromosome in cancer tissue is not fully known due to technical limitations, such as difficulties… read more here.
Keywords: chromosome loss; loss; prostate cancer; chromosome ... See more keywords
Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00296
Abstract: Faithful chromosome segregation, driven by the mitotic spindle, is essential for organismal survival. Neopolyploid cells from diverse species exhibit a significant increase in mitotic errors relative to their diploid progenitors, resulting in chromosome nondisjunction. In… read more here.
Keywords: chromosome loss; dynamics model; spindle dynamics; model ... See more keywords
HSATII RNA-dependent triplex formation in early human embryogenesis as a potential mechanism for Y chromosome loss in Turner syndrome
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2025.1731956
Abstract: Turner syndrome (TS) arises from partial or complete loss of a sex chromosome, yet the mechanistic basis for Y chromosome loss (LoY), which may contribute to a subset of TS cases, remains unclear. This article… read more here.
Keywords: turner syndrome; loss; embryogenesis; chromosome loss ... See more keywords