Meiotic defects in human oocytes: Potential causes and clinical implications
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DOI: 10.1002/bies.202200135
Abstract: Meiotic defects cause abnormal chromosome segregation leading to aneuploidy in mammalian oocytes. Chromosome segregation is particularly error‐prone in human oocytes, but the mechanisms behind such errors remain unclear. To explain the frequent chromosome segregation errors,… read more here.
Keywords: chromosome segregation; defects human; meiotic defects; human oocytes ... See more keywords
Centromere and its associated proteins—what we know about them in Plasmodium falciparum
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DOI: 10.1002/iub.1878
Abstract: The complex life cycle of intracellular parasitic protozoans entails multiple rounds of DNA replication and mitosis followed by cytokinesis to release daughter parasites. To gain insights into mitotic events it is imperative to identify the… read more here.
Keywords: centromere associated; associated proteins; falciparum; plasmodium falciparum ... See more keywords
Modeling the contributions of chromosome segregation errors and aneuploidy to Saccharomyces hybrid sterility
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DOI: 10.1002/yea.3282
Abstract: Errors in meiosis can be important postzygotic barriers between different species. In Saccharomyces hybrids, chromosomal missegregation during meiosis I produces gametes with missing or extra chromosomes. Gametes with missing chromosomes are inviable, but we do… read more here.
Keywords: hybrid sterility; sterility; contributions chromosome; modeling contributions ... See more keywords
Functional Proteomics Identifies a PICS Complex Required for piRNA Maturation and Chromosome Segregation.
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DOI: 10.1016/j.celrep.2019.05.076
Abstract: piRNAs play significant roles in suppressing transposons and nonself nucleic acids, maintaining genome integrity, and defending against viral infections. In C. elegans, piRNA precursors are transcribed in the nucleus and are subjected to a number of… read more here.
Keywords: pics complex; maturation; functional proteomics; chromosome segregation ... See more keywords
Cohesin and chromosome segregation
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DOI: 10.1016/j.cub.2018.05.019
Abstract: Summary Cohesin is a ring-shaped protein complex that organises the genome, enabling its condensation, expression, repair and transmission. Cohesin is best known for its role in chromosome segregation, where it provides the cohesion that is… read more here.
Keywords: cohesin; sister chromatids; chromosome segregation; segregation ... See more keywords
Chromosome Segregation: Evolving a Plastic Chromosome–Microtubule Interface
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DOI: 10.1016/j.cub.2019.12.058
Abstract: Despite a conserved requirement in mediating chromosome segregation, kinetochores display remarkable plasticity in their structure and composition. New work in holocentric insect species highlights the molecular rewiring that occurs when key structural components of the… read more here.
Keywords: segregation evolving; plastic chromosome; evolving plastic; chromosome segregation ... See more keywords
Chromosome Segregation Fidelity Integrates Information across Scales.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.11.027
Abstract: The influence of tissue context is an emerging theme in cell biology. Recent work reveals that tissue architecture promotes chromosome segregation fidelity in epithelia, suggesting that aneuploidy in certain cancers may arise as a consequence… read more here.
Keywords: integrates information; segregation fidelity; chromosome segregation; fidelity integrates ... See more keywords
Bactofilin-mediated organization of the ParABS chromosome segregation system in Myxococcus xanthus
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DOI: 10.1038/s41467-017-02015-z
Abstract: In bacteria, homologs of actin, tubulin, and intermediate filament proteins often act in concert with bacteria-specific scaffolding proteins to ensure the proper arrangement of cellular components. Among the bacteria-specific factors are the bactofilins, a widespread… read more here.
Keywords: parabs chromosome; myxococcus xanthus; segregation system; chromosome segregation ... See more keywords
RocS drives chromosome segregation and nucleoid protection in Streptococcus pneumoniae
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DOI: 10.1038/s41564-019-0472-z
Abstract: Chromosome segregation in bacteria is poorly understood outside some prominent model strains1–5 and even less is known about how it is coordinated with other cellular processes. This is the case for the opportunistic human pathogen… read more here.
Keywords: streptococcus pneumoniae; chromosome segregation; segregation;
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
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DOI: 10.1038/s41598-019-50702-2
Abstract: The human polo-like kinase PLK1 coordinates mitotic chromosome segregation by phosphorylating multiple chromatin- and kinetochore-binding proteins. How PLK1 activity is directed to specific substrates via phosphopeptide recognition by its carboxyl-terminal polo-box domain (PBD) is poorly… read more here.
Keywords: mitotic chromosome; pocket; plk1; chromosome segregation ... See more keywords
The RPA-RNF20-SNF2H cascade promotes proper chromosome segregation and homologous recombination repair.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2303479120
Abstract: The human tumor suppressor Ring finger protein 20 (RNF20)-mediated histone H2B monoubiquitination (H2Bub) is essential for proper chromosome segregation and DNA repair. However, what is the precise function and mechanism of RNF20-H2Bub in chromosome segregation… read more here.
Keywords: rpa rnf20; chromosome segregation; repair;