Preparing Map of Chromosome Territory Distribution Frequency.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0664-3_12
Abstract: The chromosomes in mammalian interphase nuclei are organized into domains called chromosome territories that play a major role in nuclear organization. Here we propose a methodology that combines the use of micro-patterning of adhesive molecules… read more here.
Keywords: preparing map; map chromosome; chromosome territories; geometry ... See more keywords
Enhancer dependent repositioning of TCRb locus with respect to the chromosome territory.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2022.167509
Abstract: Intranuclear position of several genes is dynamically altered during development concordant with their activation. To understand this dynamic, but non-random, nuclear organization, it is important to identify the relevant regulatory elements and trans acting factors.… read more here.
Keywords: tcrb locus; enhancer; chromosome territory;
Nascent RNA scaffolds contribute to chromosome territory architecture and counter chromatin compaction.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.07.004
Abstract: Nuclear chromosomes transcribe far more RNA than required to encode protein. Here we investigate whether non-coding RNA broadly contributes to cytological-scale chromosome territory architecture. We develop a procedure that depletes soluble proteins, chromatin, and most… read more here.
Keywords: territory architecture; chromatin compaction; rna; chromosome territory ... See more keywords
HiCTMap: Detection and analysis of chromosome territory structure and position by high-throughput imaging.
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DOI: 10.1016/j.ymeth.2018.01.013
Abstract: The spatial organization of chromosomes in the nuclear space is an extensively studied field that relies on measurements of structural features and 3D positions of chromosomes with high precision and robustness. However, no tools are… read more here.
Keywords: analysis; position; chromosome territory; chromosome ... See more keywords