Preprint Highlight: Mitotic clustering of pulverized chromosomes from micronuclei.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.p22-09-1002
Abstract: Chromosomes in micronuclei are fragmented into small pieces, sometimes catastrophically. Such severely damaged chromosomes can lead to genomic rearrangements, but how the chromosome fragments segregate during mitosis is unknown. Using live-cell imaging to follow micronuclei… read more here.
Keywords: highlight mitotic; preprint highlight; chromosomes micronuclei; chromosome fragments ... See more keywords
Mitotic clustering of pulverized chromosomes from micronuclei
Sign Up to like & getrecommendations! Published in 2022 at "Nature"
DOI: 10.1101/2022.07.19.500697
Abstract: Complex genome rearrangements can be generated by the catastrophic pulverization of missegregated chromosomes trapped within micronuclei through a process known as chromothripsis^ 1 – 5 . As each chromosome contains a single centromere, it remains… read more here.
Keywords: pulverized chromosomes; chromosomes micronuclei; clustering pulverized; mitotic clustering ... See more keywords