Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21
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DOI: 10.1371/journal.pone.0173676
Abstract: Autophagy is a catabolic mechanism to degrade cellular components to maintain cellular energy levels during starvation, a condition where PPARα may be activated. Here we report a reduced autophagic capacity in the liver following chronic… read more here.
Keywords: ppar; autophagic proteins; chronic activation; ppar fenofibrate ... See more keywords
Chronic Activation of Gp1 mGluRs Leads to Distinct Refinement of Neural Network Activity through Non-Canonical p53 and Akt Signaling
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DOI: 10.1523/eneuro.0438-19.2020
Abstract: Abstract Group 1 metabotropic glutamate receptors (Gp1 mGluRs), including mGluR1 and mGluR5, are critical regulators for neuronal and synaptic plasticity. Dysregulated Gp1 mGluR signaling is observed with various neurologic disorders, including Alzheimer’s disease, Parkinson’s disease,… read more here.
Keywords: gp1; activity; gp1 mglurs; activation gp1 ... See more keywords