Lack of dopamine supersensitivity in rats after chronic administration of blonanserin: Comparison with haloperidol
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.04.014
Abstract: Abstract Long‐term treatment with antipsychotic drugs in patients with schizophrenia can lead to dopamine supersensitivity psychosis. It is reported that repeated administration of haloperidol caused dopamine supersensitivity in rats. Blonanserin is an atypical antipsychotic drug… read more here.
Keywords: chronic administration; blonanserin; dopamine supersensitivity; dopamine ... See more keywords
Chronic administration of gonadotropin releasing-hormone improves learning in old gonadectomized rats
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2018.11.010
Abstract: &NA; The aim of this study was to determine whether chronic administration of GnRH improves performance of learning tasks and expression of spinophilin in the hippocampus of gonadectomized old rats. Eighteen‐month‐old male Wistar rats were… read more here.
Keywords: improves learning; learning old; chronic administration; gnrh ... See more keywords
Biochemical and histopathological analysis after sub-chronic administration of oxyresveratrol in Wistar rats.
Sign Up to like & getrecommendations! Published in 2021 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2021.2015243
Abstract: Oxyresveratrol (OXY) is a naturally occurring phenolic compound; however, there are no toxicity studies reported on its long term use. The aim of our work was to demonstrate the evaluation of acute and sub-chronic toxicity… read more here.
Keywords: chronic administration; sub chronic; wistar rats; oxyresveratrol ... See more keywords
Why Multitarget Vasodilatory (Endo)cannabinoids Are Not Effective as Antihypertensive Compounds after Chronic Administration: Comparison of Their Effects on Systemic and Pulmonary Hypertension
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DOI: 10.3390/ph15091119
Abstract: Systemic and pulmonary hypertension are multifactorial, high-pressure diseases. The first one is a civilizational condition, and the second one is characterized by a very high mortality rate. Searching for new therapeutic strategies is still an… read more here.
Keywords: pulmonary hypertension; endo cannabinoids; systemic pulmonary; hypertension ... See more keywords