Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_90
Abstract: Neural mechanisms underlying alcohol use disorder remain elusive, and this lack of understanding has slowed the development of efficacious treatment strategies for reducing relapse rates and prolonging abstinence. While synaptic adaptations produced by chronic alcohol… read more here.
Keywords: potassium channels; hyperpolarization; intrinsic excitability; chronic alcohol ... See more keywords
Multi-omics integration reveals the hepatoprotective mechanisms of ursolic acid intake against chronic alcohol consumption
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nutrition"
DOI: 10.1007/s00394-021-02632-x
Abstract: Alcoholic liver disease (ALD) is a major health issue globally. In addition to pharmacotherapy, dietary support is also regarded as reliable strategy for ALD management. As a widely distributed natural constituent within edible plants, the… read more here.
Keywords: integration; alcoholic liver; ursolic acid; liver injury ... See more keywords
Effect of RGPU-260, a Novel GABA Derivative, on Functional Reserves of Rat Heart after Chronic Alcohol Intoxication.
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of experimental biology and medicine"
DOI: 10.1007/s10517-021-05121-7
Abstract: The effect of a new derivative of GABA, the compound RGPU-260, on the heart contractility of rats exposed to chronic alcohol intoxication (10% ethanol solution for 24 weeks) was studied. In comparison with intact rats,… read more here.
Keywords: heart; alcohol intoxication; effect; gaba ... See more keywords
PDE5 inhibitor sildenafil attenuates cardiac microRNA 214 upregulation and pro-apoptotic signaling after chronic alcohol ingestion in mice
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03779-7
Abstract: Abusive chronic alcohol consumption can cause metabolic and functional derangements in the heart and is a risk factor for development of non-ischemic cardiomyopathy. microRNA 214 (miR-214) is a molecular sensor of stress signals that negatively… read more here.
Keywords: pde5 inhibitor; microrna 214; sildenafil; mir 214 ... See more keywords
Spinal AMPA Receptor GluA1 Ser831 Phosphorylation Controls Chronic Alcohol Consumption-Produced Prolongation of Postsurgical Pain
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0639-7
Abstract: Previous studies have shown that excessive alcohol drinking is associated with chronic pain development; however, the molecular mechanism underlying this association is poorly understood. In this study, we investigated the effect of chronic alcohol consumption… read more here.
Keywords: alcohol consumption; ampa receptor; chronic alcohol; alcohol ... See more keywords
Acute and chronic alcohol use correlated with methods of suicide in a Swiss national sample.
Sign Up to like & getrecommendations! Published in 2017 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2017.05.009
Abstract: OBJECTIVES Chronic and acute alcohol use are highly associated risk factors for suicides worldwide. Therefore, we examined suicide cases with and without alcohol use disorder (AUD) using data from the SNSF project "Suicide in Switzerland:… read more here.
Keywords: acute; methods suicide; chronic alcohol; alcohol ... See more keywords
Chronic alcohol abuse may lead to high skin iron content, but not to hepatic siderosis.
Sign Up to like & getrecommendations! Published in 2019 at "Forensic science international"
DOI: 10.1016/j.forsciint.2019.06.009
Abstract: INTRODUCTION In forensic cases, ante mortem chronic alcohol abuse can be of central importance in clarifying circumstances of death. However, reliable markers of alcohol consumption, which are still available postmortem, are needed. In addition to… read more here.
Keywords: alcohol abuse; siderosis; iron; chronic alcohol ... See more keywords
Hippocampal granule cell loss in human chronic alcohol abusers
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.08.011
Abstract: Chronic alcohol abuse causes cognitive impairments associated with neurodegeneration and volume loss in the human hippocampus. Here, we hypothesize that alcohol reduces the number of granule cells in the human dentate gyrus and consequently contribute… read more here.
Keywords: granule; number; chronic alcohol; cell ... See more keywords
Unraveling the Impact of TLR4 and Sex on Chronic Alcohol Consumption-Induced Lipidome Dysregulation in Extracellular Vesicles.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.4c00786
Abstract: The lipids that form extracellular vesicles (EVs) play critical structural and regulatory roles, and cutting-edge bioinformatics strategies have shown the ability to decipher lipid metabolism and related molecular mechanisms. We previously demonstrated that alcohol abuse… read more here.
Keywords: extracellular vesicles; chronic alcohol; alcohol consumption; sex ... See more keywords
Dose-dependent effects of chronic alcohol drinking on peripheral immune responses
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44302-3
Abstract: It is well established that chronic heavy alcohol drinking (CHD) results in significant organ damage, increased susceptibility to infections, and poor outcomes following injury. In contrast, chronic moderate drinking (CMD) has been associated with improved… read more here.
Keywords: dependent effects; alcohol; dose dependent; chronic alcohol ... See more keywords
Restricted immunological and cellular pathways are shared by murine models of chronic alcohol consumption
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-59188-9
Abstract: Murine models of chronic alcohol consumption are frequently used to investigate alcoholic liver injury and define new therapeutic targets. Lieber-DeCarli diet (LD) and Meadows-Cook diet (MC) are the most accepted models of chronic alcohol consumption.… read more here.
Keywords: models chronic; murine models; alcohol consumption; chronic alcohol ... See more keywords