Tolerance and dependence following chronic alprazolam treatment in rhesus monkeys: Role of GABAA receptor subtypes.
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DOI: 10.1016/j.drugalcdep.2021.108985
Abstract: BACKGROUND To assess GABAA receptor subtypes involved in benzodiazepine tolerance and dependence, we evaluated the ability of subtype-selective and non-selective ligands to substitute for (i.e., produce "cross-tolerance") or precipitate withdrawal during chronic alprazolam treatment. METHODS… read more here.
Keywords: gabaa receptor; tolerance; chronic alprazolam; receptor subtypes ... See more keywords