Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2017.03.039
Abstract: Nuclear factor of activated T cells 5 (NFAT5) has been implicated in the pathogenesis of various human diseases, including cancer and arthritis. However, therapeutic agents inhibiting NFAT5 activity are currently unavailable. To discover NFAT5 inhibitors,… read more here.
Keywords: chronic arthritis; nfat5 mediated; suppression nfat5; nfat5 activity ... See more keywords
Anti-rheumatic, and analgesic effects by the parent tuberous roots of Aconitum jaluense in adjuvant induced arthritis rats.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114518
Abstract: AIM OF THE STUDY The aim of this study was to test the anti-rheumatic effects of A. jaluense tubers in acute and chronic arthritis rats, and to assign its ingredients through UPLC-TOF/MS. MATERIALS AND METHODS… read more here.
Keywords: jaluense tubers; chronic arthritis; anti rheumatic; arthritis rats ... See more keywords
Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06581-6
Abstract: Inflammatory activity in rheumatoid arthritis may alter the regulation of muscle mass leading to a secondary sarcopenia, commonly termed rheumatoid cachexia (RC). We characterized alterations to muscle structure and various pro-inflammatory, catabolic and regenerative markers… read more here.
Keywords: chronic arthritis; arthritis; signaling sarcopenia; sarcopenia experimental ... See more keywords
Reduced prescription of TNF-inhibitors in chronic arthritis based on therapeutic drug monitoring: A randomized controlled trial.
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian journal of rheumatology"
DOI: 10.1080/03009742.2022.2121081
Abstract: OBJECTIVE Dosing of tumour necrosis factor-α inhibitors (TNFis) is not personalized causing interindividual variation in serum drug levels; however, dose optimization is not widely implemented. We hypothesized that some patients are overdosed; thus, drug prescription… read more here.
Keywords: prescription; therapeutic drug; drug monitoring; drug ... See more keywords
SAT0060 CHOLESTEROL SEQUESTERING IN MACROPHAGES CONTRIBUTES TO THE LIPID PARADOX IN CHRONIC ARTHRITIS
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.4318
Abstract: Background: Patients with active rheumatoid arthritis (RA) have increased cardiovascular mortality, paradoxically associated with reduced circulating lipid levels (1-3). Several disease-modifying antirheumatic drugs (DMARDs), such as the JAK inhibitor tofacitinib, ameliorate disease activity along with… read more here.
Keywords: chronic arthritis; control; cia; cholesterol ... See more keywords
Engagement and attrition with eHealth tools for remote monitoring in chronic arthritis: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "RMD Open"
DOI: 10.1136/rmdopen-2022-002625
Abstract: Objectives Although eHealth tools are potentially useful for remote disease monitoring, barriers include concerns of low engagement and high attrition. We aimed to summarise evidence on patients’ engagement and attrition with eHealth tools for remotely… read more here.
Keywords: attrition; ehealth; ehealth tools; remote monitoring ... See more keywords
Antibody response patterns in chikungunya febrile phase predicts protection versus progression to chronic arthritis.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.130509
Abstract: Chikungunya virus (CHIKV) infection causes acute febrile illness in humans and some of these individuals develop a debilitating chronic arthritis that can persist for months to years for reasons that remain poorly understood. In this… read more here.
Keywords: febrile phase; chronic arthritis; antibody; antibody response ... See more keywords
Mobile Health Features Supporting Self-Management Behavior in Patients With Chronic Arthritis: Mixed-Methods Approach on Patient Preferences
Sign Up to like & getrecommendations! Published in 2019 at "JMIR mHealth and uHealth"
DOI: 10.2196/12535
Abstract: Background Patients with chronic arthritis (CA) ideally apply self-management behaviors between consultations. This enduring, tedious task of keeping track of disease-related parameters, adhering to medication schemes, and engaging in physical therapy may be supported by… read more here.
Keywords: chronic arthritis; disease; management; patients chronic ... See more keywords