PARP inhibition by olaparib alleviates chronic asthma‐associated remodeling features via modulating inflammasome signaling in mice
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DOI: 10.1002/iub.2048
Abstract: Despite the reported role of poly(ADP‐ribose) polymerase (PARP) in asthma inflammation, its contribution during remodeling is not clearly known. The main aim of the current investigation was to examine the potential of olaparib, a pharmacological… read more here.
Keywords: olaparib; via modulating; inflammasome signaling; chronic asthma ... See more keywords
Diagnosis, monitoring and management of chronic asthma
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DOI: 10.1002/psb.1665
Abstract: In November 2017, NICE published a new guideline on the diagnosis and management of chronic asthma (NG80). This article provides an overview of the guidance, and how it differs from the 2016 joint British Thoracic… read more here.
Keywords: diagnosis monitoring; management chronic; chronic asthma;
Progressive increase in allergen concentration abrogates immune tolerance in ovalbumin‐induced murine model of chronic asthma
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.04.047
Abstract: ABSTRACT Persistent inflammation and remodeling of airways are the major hallmarks of asthma. Though airway inflammation diminishes in ovalbumin (OVA)‐based mouse model of chronic asthma owing to immune‐tolerance linked with repeated allergen exposure, which limits… read more here.
Keywords: inflammation; chronic asthma; model; model chronic ... See more keywords
Comparing executive functions between patients with chronic asthma and healthy subjects
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Asthma"
DOI: 10.1080/02770903.2017.1337786
Abstract: ABSTRACT Objective: Allergic diseases have different levels of prevalence all over the world. Among them, asthma is the most common chronic disease. Up to now, little attention has been paid to the impact of this… read more here.
Keywords: asthma healthy; executive functions; functions patients; chronic asthma ... See more keywords
Development and Pilot Testing of a Computerized Asthma Kiosk to Initiate Chronic Asthma Care in a Pediatric Emergency Department
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DOI: 10.1097/pec.0000000000001630
Abstract: Objectives Emergency department (ED) visits are an opportunity to initiate chronic asthma care. Ideally, this care should be implemented in a fashion that limits utilization of scarce ED resources. We developed, iteratively refined, and pilot… read more here.
Keywords: asthma care; chronic asthma; pilot; asthma ... See more keywords
Progranulin Protects Against Airway Remodeling Through the Modulation of Autophagy via HMGB1 Suppression in House Dust Mite-Induced Chronic Asthma
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DOI: 10.2147/jir.s322724
Abstract: Purpose Airway remodeling is an important feature of chronic asthma, and yet there are few effective therapeutic strategies. Progranulin (PGRN) has been shown to have lung protective functions, but the role of PGRN in asthmatic… read more here.
Keywords: house dust; chronic asthma; airway remodeling; hdm ... See more keywords
ORMDL3 Promotes Angiogenesis in Chronic Asthma Through the ERK1/2/VEGF/MMP-9 Pathway
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DOI: 10.3389/fped.2021.708555
Abstract: Aim Angiogenesis plays a vital role in airway remodeling in chronic asthma. ORMDL3 has been identified to be closely associated with the development of asthma remodeling. This study was to investigate the mechanism of ORMDL3… read more here.
Keywords: chronic asthma; group; asthma; vegf mmp ... See more keywords
Expression of Muscarinic Receptors and the Effect of Tiotropium Bromide in Aged Mouse Model of Chronic Asthma
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DOI: 10.4046/trd.2018.0049
Abstract: Background Efficacy and safety of tiotropium bromide, a muscarinic receptor antagonist, in treatment of asthma have been reported. However, its effect on airway remodeling in chronic asthma of the elderly has not been clearly verified.… read more here.
Keywords: tiotropium bromide; tiotropium; expression muscarinic; muscarinic receptors ... See more keywords