Intestinal permeability evaluation in patients with chronic Chagas heart failure
Sign Up to like & getrecommendations! Published in 2023 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14156
Abstract: We analysed intestinal permeability in patients with chronic Chagas cardiomyopathy (CCC) and evaluated its association with clinical manifestations, haemodynamic parameters measured by echocardiogram, and disease outcome. Intestinal permeability was compared between CCC patients and a… read more here.
Keywords: heart failure; chronic chagas; patients chronic; intestinal permeability ... See more keywords
Sacubitril/valsartan versus enalapril in chronic Chagas cardiomyopathy with heart failure: Baseline characteristics of the PARACHUTE-HF trial.
Sign Up to like & getrecommendations! Published in 2025 at "European journal of heart failure"
DOI: 10.1002/ejhf.70026
Abstract: The PARACHUTE‐HF trial (NCT04023227) is evaluating the effect of sacubitril/valsartan compared with enalapril on a hierarchical composite of cardiovascular events (cardiovascular death, first heart failure hospitalization), and change in N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) levels… read more here.
Keywords: heart; parachute trial; chronic chagas; sacubitril valsartan ... See more keywords
Chronic Chagas disease: quantification of Trypanosoma cruzi in peripheral blood and dejections of Triatoma infestans fed by xenodiagnosis in patients with and without cardiopathy.
Sign Up to like & getrecommendations! Published in 2019 at "Acta tropica"
DOI: 10.1016/j.actatropica.2019.105167
Abstract: It is not currently known which individuals with chronic Chagas disease (ChD) will develop cardiopathy in a determined period and which will be maintained asymptomatic with normal routine laboratory tests all their lives. The parasite… read more here.
Keywords: qpcr; without cardiopathy; fed xenodiagnosis; chronic chagas ... See more keywords
Immunological exhaustion and functional profile of CD8+ T lymphocytes as cellular biomarkers of therapeutic efficacy in chronic Chagas patients.
Sign Up to like & getrecommendations! Published in 2019 at "Acta tropica"
DOI: 10.1016/j.actatropica.2019.105242
Abstract: The lack of useful tools for detection the impact of treatment during the follow-up of chronic Chagas disease treated patients difficult the adequate care to the affected population. The objective of this study was to… read more here.
Keywords: benznidazole treatment; cd8; chagas patients; treatment ... See more keywords
Noninvasive prediction of late potentials in the signal-averaged ECG in patients with chronic Chagas disease.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of electrocardiology"
DOI: 10.1016/j.jelectrocard.2021.09.011
Abstract: INTRODUCTION Considering the importance of ventricular arrhythmias in the prediction of sudden cardiac death in chronic Chagas heart disease, the aim of the present study was to associate late potentials observed in the signal-averaged electrocardiogram… read more here.
Keywords: signal averaged; disease; patients chronic; late potentials ... See more keywords
IgE antibodies against Trypanosoma cruzi arginine kinase in patients with chronic Chagas disease.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular immunology"
DOI: 10.1016/j.molimm.2021.06.024
Abstract: Arginine kinase (AK) is an enzyme present in various invertebrates, as well as in some trypanosomatids such as T. cruzi, the etiological agent that causes Chagas disease. In invertebrates, this protein acts as an allergen… read more here.
Keywords: ige; arginine kinase; patients chronic; chronic chagas ... See more keywords
Long-term prognosis and predictors of death in chronic Chagas cardiomyopathy in women and men
Sign Up to like & getrecommendations! Published in 2024 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehae666.3081
Abstract: Chronic Chagas cardiomyopathy (CCC) is one of the leading causes of heart failure (HF) in Latin America and carries high morbidity and mortality. Previous studies showed conflicting results in epidemiological and clinical evidence of a… read more here.
Keywords: age; predictors death; prognosis; women men ... See more keywords
Systemic microvascular endothelial dysfunction is associated with left ventricular ejection fraction reduction in chronic Chagas disease patients
Sign Up to like & getrecommendations! Published in 2020 at "Microcirculation"
DOI: 10.1111/micc.12664
Abstract: This study compares microvascular reactivity (MR) in chronic Chagas disease (CD) patients with healthy individuals, matched for sex and age. In addition, we evaluated the association between MR and left ventricular ejection fraction (LVEF) in… read more here.
Keywords: disease patients; ejection fraction; ventricular ejection; chronic chagas ... See more keywords
New Biomarker in Chagas Disease: Extracellular Vesicles Isolated from Peripheral Blood in Chronic Chagas Disease Patients Modulate the Human Immune Response
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Immunology Research"
DOI: 10.1155/2021/6650670
Abstract: Chagas disease, a neglected tropical disease (NTD) caused by the flagellated protozoan Trypanosoma cruzi (T. cruzi), is a major public health problem. It was initially restricted to Latin America, but it is now expanding globally.… read more here.
Keywords: extracellular vesicles; disease; circulating evs; chronic chagas ... See more keywords
Rapid diagnostic tests and ELISA for diagnosing chronic Chagas disease: Systematic revision and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0010860
Abstract: Objective To determine the diagnostic validity of the enzyme-linked immunosorbent assay (ELISA) and Rapid Diagnostic Tests (RDT) among individuals with suspected chronic Chagas Disease (CD). Methodology A search was made for studies with ELISA and… read more here.
Keywords: diagnostic tests; rapid diagnostic; chronic chagas; chagas disease ... See more keywords
Trypanocidal Treatment for Chronic Chagas Disease: Past, Present, and Future
Sign Up to like & getrecommendations! Published in 2025 at "Revista da Sociedade Brasileira de Medicina Tropical"
DOI: 10.1590/0037-8682-0242-2025
Abstract: ABSTRACT This article reviews the trypanocidal therapy for chronic Chagas disease, emphasizing its indications, efficacy, limitations, and future perspectives. The etiological treatment is based on the use of benznidazole and nifurtimox, both of which were… read more here.
Keywords: chronic chagas; chagas disease; treatment; trypanocidal treatment ... See more keywords