Paeonol inhibits chronic constriction injury‐induced astrocytic activation and neuroinflammation in rats via the HDAC/miR‐15a pathway
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21993
Abstract: Neuropathic pain affects millions of people in the worldwide, but the major therapeutics perform limited effectiveness. Paeonol (PAE) is widely distributed in Paeonis albiflora, and has manifested anti‐inflammatory and antioxidative effects in multiple diseases. The… read more here.
Keywords: hdac mir; paeonol; astrocytic activation; constriction injury ... See more keywords
Chronic constriction injury of the sciatic nerve in rats causes different activation modes of microglia between the anterior and posterior horns of the spinal cord
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2020.104672
Abstract: Chronic constriction injury of the sciatic nerve is frequently considered as a cause of chronic neuropathic pain. Marked activation of microglia in the posterior horn (PH) has been well established with regard to this pain.… read more here.
Keywords: activation modes; modes microglia; chronic constriction; activation ... See more keywords
Comparison of sildenafil, fluoxetine and its co-administration against chronic constriction injury induced neuropathic pain in rats: An influential additive effect
Sign Up to like & getrecommendations! Published in 2019 at "Neurological Research"
DOI: 10.1080/01616412.2019.1630091
Abstract: ABSTRACT Current drug treatment available for neuropathic pain (NP) provides meager and partial pain relief due to incomplete efficacy and dose-dependent adverse effect. Hence, combination therapy can provide prolongation in analgesic effect with milder side… read more here.
Keywords: sildenafil fluoxetine; effect; chronic constriction; neuropathic pain ... See more keywords
IL-6 contributes to Nav1.3 up-regulation in trigeminal nerve following chronic constriction injury
Sign Up to like & getrecommendations! Published in 2020 at "Neurological Research"
DOI: 10.1080/01616412.2020.1747719
Abstract: ABSTRACT Background: To verify the hypothesis that the nature of trigeminal neuralgia (TN) is an ectopic impulse induced by sodium channel modulated by cytokines, we conducted an animal study using the infraorbital nerve chronic constriction… read more here.
Keywords: trigeminal nerve; group; chronic constriction; cci group ... See more keywords
Artichoke leaf hydroethanolic extract reduces neuropathic pain in a rat model of chronic constriction injury via attenuating the sciatic nerve oxidative stress
Sign Up to like & getrecommendations! Published in 2024 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2024.2406898
Abstract: Abstract Neuropathic pain, a nerve damage consequence, presents symptoms such as dysesthesia, hyperalgesia, and allodynia. This study aimed to evaluate the alleviating potential of artichoke leaf extract in neuropathic pain induced by chronic constriction injury… read more here.
Keywords: sciatic nerve; artichoke leaf; constriction injury; nerve ... See more keywords
Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats
Sign Up to like & getrecommendations! Published in 2022 at "Channels"
DOI: 10.1080/19336950.2021.2023383
Abstract: ABSTRACT The voltage-gated sodium channel isoform NaV1.7 is a critical player in the transmission of nociceptive information. This channel has been heavily implicated in human genetic pain disorders and is a validated pain target. However,… read more here.
Keywords: small molecule; chronic constriction; constriction injury; injury ... See more keywords
Cannabidiol Treatment Shows Therapeutic Efficacy in a Rodent Model of Social Transfer of Pain in Pair-Housed Male Mice.
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DOI: 10.1089/can.2022.0300
Abstract: Introduction: Prosocial behavior refers to sharing emotions and sensations such as pain. Accumulated data indicate that cannabidiol (CBD), a nonpsychotomimetic component of the Cannabis sativa plant, attenuates hyperalgesia, anxiety, and anhedonic-like behavior. Nevertheless, the role… read more here.
Keywords: chronic constriction; pain; cbd; like behavior ... See more keywords
Octanol alleviates chronic constriction injury of sciatic nerve-induced peripheral neuropathy by regulating AKT/mTOR signaling
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Orthopaedic Surgery"
DOI: 10.1177/10225536241273556
Abstract: Objective Activation of gap junction channels can induce neuropathic pain. Octanol can limit the conductance of gap junctions containing connexin 43 proteins. Thus, this study focused on the roles of octanol in chronic constriction injury… read more here.
Keywords: octanol; akt mtor; chronic constriction; cci ... See more keywords
Effects of microRNA-223 on morphine analgesic tolerance by targeting NLRP3 in a rat model of neuropathic pain
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DOI: 10.1177/1744806917706582
Abstract: Objective To investigate the effects of microRNA-223 on morphine analgesic tolerance by targeting NLRP3 in a rat model of neuropathic pain. Methods Our study selected 100 clean grade healthy Sprague-Dawley adult male rats weighing 200… read more here.
Keywords: 223 morphine; morphine; chronic constriction; mir 223 ... See more keywords
Astrocyte-microglia interaction through C3/C3aR pathway modulates neuropathic pain in rats model of chronic constriction injury
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pain"
DOI: 10.1177/17448069221140532
Abstract: Neuropathic pain (NP) is the cardinal symptom of neural injury, and its underlying molecular mechanism needs further investigation. Complements, especially complement 3 (C3), are involved in the pathophysiology of many neurological disorders, while the specific… read more here.
Keywords: constriction injury; neuropathic pain; pain; c3ar ... See more keywords
Exploring the Mechanism of Immediate Analgesia Induced by Tuina Intervention on Minor Chronic Constriction Injury in Rats Using LC-MS
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Pain Research"
DOI: 10.2147/jpr.s438682
Abstract: Purpose This study aimed to investigate changes in metabolomic expression in the spinal dorsal horn (SDH) and thalamus during a Tuina session, aiming to elucidate the mechanism of immediate analgesia. Methods The rats were randomly… read more here.
Keywords: chronic constriction; group; immediate analgesia; mechanism immediate ... See more keywords