Clinical Formulation Bridging of Gefapixant, a P2X3‐Receptor Antagonist, for the Treatment of Chronic Cough
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DOI: 10.1002/cpdd.1105
Abstract: Gefapixant is a P2X3‐receptor antagonist being developed for treatment of refractory or unexplained chronic cough. Four phase 1 studies were conducted in healthy participants that bridged the early‐phase gefapixant formulation (F01) to the phase 3… read more here.
Keywords: receptor antagonist; formulation; chronic cough; p2x3 receptor ... See more keywords
A child with chronic cough and eosinophilia secondary to Strongyloides stercoralis infection
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.26048
Abstract: we presented the case of a 3-year-old, Caucasian female, with history of severe persistent asthma, who presented with chronic cough. Symptoms were present since 18 months of age but worsened in the 5 months prior… read more here.
Keywords: eosinophilia secondary; chronic cough; cough; cough eosinophilia ... See more keywords
Chronic cough related to the upper airway cough syndrome: one entity but not always the same
Sign Up to like & getrecommendations! Published in 2020 at "European Archives of Oto-Rhino-Laryngology"
DOI: 10.1007/s00405-020-06071-y
Abstract: Purpose Upper airway cough syndrome (UACS), described as chronic cough (CC) associated with allergic (AR), non-allergic rhinitis (NAR) or chronic rhinosinusitis (CRS), is one of the major causes of CC. We aimed to characterize a… read more here.
Keywords: airway cough; cough; cough syndrome; upper airway ... See more keywords
Characterization of Patients With Refractory or Unexplained Chronic Cough Participating in a Phase 2 Clinical Trial of the P2X3-Receptor Antagonist Gefapixant
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DOI: 10.1007/s00408-021-00437-7
Abstract: This analysis assesses clinical characteristics of patients with refractory chronic cough (RCC) or unexplained chronic cough (UCC) enrolled in a phase 2 study to better understand this patient population. Patients with RCC/UCC lasting for ≥ 1 year… read more here.
Keywords: phase; unexplained chronic; cough; patients refractory ... See more keywords
Evaluation of children with chronic cough including obstructive sleep apnea: a single-center experience
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DOI: 10.1007/s00431-018-3276-x
Abstract: Chronic cough in children may be due to a diverse range of etiologies. We aimed to evaluate children with chronic cough following a standardized cough algorithm and assess obstructive sleep apnea (OSA) as a possible… read more here.
Keywords: chronic cough; cough; children chronic; obstructive sleep ... See more keywords
Chronic laryngopharyngeal vagal neuropathy.
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DOI: 10.1016/j.bjorl.2018.04.001
Abstract: Dysphonia, vocal fold paresis, laryngopharyngeal reflux disease (LPRD), chronic cough, globus, and laryngospasm are all common disorders seen by otolaryngologists. There is clear overlap in these disorders in some patients but in other patients the… read more here.
Keywords: vagal neuropathy; vagus nerve; chronic laryngopharyngeal; chronic cough ... See more keywords
Change in Psychological, Physiological, and Situational Factors in Adults After Treatment of Chronic Cough
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DOI: 10.1016/j.chest.2017.06.024
Abstract: BACKGROUND: We hypothesized that addressing anxiety and depressive mood disorders will improve chronic cough severity and cough quality of life (CQOL). METHODS: Major tenets of the theory of unpleasant symptoms were examined in a longitudinal… read more here.
Keywords: improvement; significantly associated; cough; cqol ... See more keywords
Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report.
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DOI: 10.1016/j.chest.2020.02.015
Abstract: BACKGROUND Chronic cough due to chronic bronchitis (CB) causes significant impairment in quality of life and effective treatment strategies are needed. We conducted a systematic review on the management of chronic cough due to CB… read more here.
Keywords: cough; cough due; chronic bronchitis; stable chronic ... See more keywords
Applying interpretable deep learning models to identify chronic cough patients using EHR data
Sign Up to like & getrecommendations! Published in 2021 at "Computer methods and programs in biomedicine"
DOI: 10.1016/j.cmpb.2021.106395
Abstract: BACKGROUND AND OBJECTIVE Chronic cough (CC) affects approximately 10% of adults. Many disease states are associated with chronic cough, such as asthma, upper airway cough syndrome, bronchitis, and gastroesophageal reflux disease. The lack of an… read more here.
Keywords: learning models; ehr data; deep learning; cough ... See more keywords
A Case of Chronic Cough in a Winemaker
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DOI: 10.1016/j.rmcr.2017.03.014
Abstract: Background Fungi have been known to cause a variety of respiratory conditions, ranging from mold- associated asthma to allergic bronchopulmonary mycosis and invasive disease. More recently some fungal species have been implicated in a non-asthmatic… read more here.
Keywords: saccharomyces cerevisiae; case chronic; cough; cough winemaker ... See more keywords
[Cryptogenic organising pneumonia as a cause of chronic cough].
Sign Up to like & getrecommendations! Published in 2018 at "Semergen"
DOI: 10.1016/j.semerg.2017.05.003
Abstract: La tos es uno de los síntomas respiratorios más frecuentes en la consulta de atención primaria. Su persistencia puede producir una repercusión importante en la vida de los pacientes y en ocasiones ser el síntoma… read more here.
Keywords: organising pneumonia; con; cause chronic; chronic cough ... See more keywords