Chronic ethanol exposure differentially alters neuronal function in the medial prefrontal cortex and dentate gyrus
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108438
Abstract: Alterations in the function of prefrontal cortex (PFC) and hippocampus have been implicated in underlying the relapse to alcohol seeking behaviors in humans and animal models of moderate to severe alcohol use disorders (AUD). Here… read more here.
Keywords: ethanol exposure; exposure; excitability; chronic ethanol ... See more keywords
Chronic Ethanol Exposure Potentiates Cholinergic Neurotransmission in the Basolateral Amygdala
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.12.014
Abstract: Chronic intermittent ethanol (CIE) exposure dysregulates glutamatergic and GABAergic neurotransmission, facilitating BLA pyramidal neuron hyperexcitability and the expression of anxiety during withdrawal. It is unknown whether ethanol-induced alterations in nucleus basalis magnocellularis (NBM) cholinergic projections… read more here.
Keywords: cie; exposure; cholinergic neurotransmission; ethanol ... See more keywords
Concurrent gut transcriptome and microbiota profiling following chronic ethanol consumption in nonhuman primates
Sign Up to like & getrecommendations! Published in 2018 at "Gut Microbes"
DOI: 10.1080/19490976.2018.1441663
Abstract: ABSTRACT Alcohol use disorder (AUD) results in increased intestinal permeability, nutrient malabsorption, and increased risk of colorectal cancer (CRC). Our understanding of the mechanisms underlying these morbidities remains limited because studies to date have relied… read more here.
Keywords: ethanol consumption; chronic ethanol; consumption; concurrent gut ... See more keywords
Evidence of Altered Mitochondrial Protein Expression After Chronic Ethanol Consumption in the Aged Estrogen‐Deficient Female Rat Heart
Sign Up to like & getrecommendations! Published in 2017 at "Alcoholism: Clinical and Experimental Research"
DOI: 10.1111/acer.13421
Abstract: BACKGROUND Estrogen loss has been implicated to increase the risk of alcoholic cardiomyopathy in postmenopausal women. The purpose of this study was to identify novel mitochondrial protein targets for the treatment of alcoholic cardiomyopathy in… read more here.
Keywords: protein expression; mitochondrial protein; heart; rat heart ... See more keywords
Chronic Ethanol Administration Prevents Compensatory Cardiac Hypertrophy in Pressure Overload
Sign Up to like & getrecommendations! Published in 2018 at "Alcoholism: Clinical and Experimental Research"
DOI: 10.1111/acer.13799
Abstract: BACKGROUND Alcohol is among the most commonly abused drugs worldwide and affects many organ systems, including the heart. Alcoholic cardiomyopathy is characterized by a dilated cardiac phenotype with extensive hypertrophy and extracellular matrix (ECM) remodeling.… read more here.
Keywords: collagen; administration; pressure overload; hypertrophy ... See more keywords
Chronic Ethanol Differentially Modulates Glutamate Release from Dorsal and Ventral Prefrontal Cortical Inputs onto Rat Basolateral Amygdala Principal Neurons
Sign Up to like & getrecommendations! Published in 2019 at "eNeuro"
DOI: 10.1523/eneuro.0132-19.2019
Abstract: Abstract The medial prefrontal cortex (mPFC) and the basolateral amygdala (BLA) have strong reciprocal connectivity. Projections from the BLA to the mPFC can drive innate, anxiety-related behaviors, but it is unclear whether reciprocal projections from… read more here.
Keywords: chronic ethanol; glutamate release; withdrawal; bla ... See more keywords
Chronic ethanol exposure impairs alveolar leukocyte infiltration during pneumococcal pneumonia, leading to an increased bacterial burden despite increased CXCL1 and nitric oxide levels
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1175275
Abstract: Ethanol abuse is a risk factor for the development of pneumonia caused by Streptococcus pneumoniae, a critical pathogen for public health. The aim of this article was to investigate the inflammatory mechanisms involved in pneumococcal… read more here.
Keywords: pneumococcal pneumonia; ethanol exposure; chronic ethanol; ethanol ... See more keywords
Multiomics Approach Captures Hepatic Metabolic Network Altered by Chronic Ethanol Administration
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology12010028
Abstract: Simple Summary The liver sustains the greatest damage from heavy alcohol consumption because alcohol is primarily detoxified in the liver. Accumulation of fat in the liver cells (hepatocytes) is one of the first pathological changes… read more here.
Keywords: administration; fatty liver; chronic ethanol; ethanol administration ... See more keywords
Molecular Aspects of Hypoxic Stress Effects in Chronic Ethanol Exposure of Neuronal Cells
Sign Up to like & getrecommendations! Published in 2023 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb45020107
Abstract: Experimental models of a clinical, pathophysiological context are used to understand molecular mechanisms and develop novel therapies. Previous studies revealed better outcomes for spinal cord injury chronic ethanol-consuming patients. This study evaluated cellular and molecular… read more here.
Keywords: ethanol exposure; chronic ethanol; ethanol; hypoxic stress ... See more keywords
Synbiotics Alleviate Hepatic Damage, Intestinal Injury and Muscular Beclin-1 Elevation in Rats after Chronic Ethanol Administration
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222212547
Abstract: The purpose of this study was to investigate the beneficial effects of synbiotics on liver damage, intestinal health, and muscle loss, and their relevance in rats with chronic ethanol feeding. Thirty Wistar rats fed with… read more here.
Keywords: control; group; rats chronic; liquid diet ... See more keywords
Remodeling of the duct system of the rat submandibular salivary glands in chronic ethanol intoxication.
Sign Up to like & getrecommendations! Published in 2020 at "Wiadomosci lekarskie"
DOI: 10.36740/wlek202001125
Abstract: OBJECTIVE The aim: To determine the dynamics of changes in metric parameters of the duct system of rat submandibular glands in normal conditions and chronic ethanol intoxication. PATIENTS AND METHODS Materials and methods: 50 albino… read more here.
Keywords: chronic ethanol; system; rat submandibular; system rat ... See more keywords