Prognostic Value of Cutaneous Disease Severity Estimates on Survival Outcomes in Patients With Chronic Graft-vs-Host Disease.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2022.6624
Abstract: Importance Prior studies have demonstrated an association between cutaneous chronic graft-vs-host disease (cGVHD) and mortality. Assessment of the prognostic value of different measures of disease severity would assist in risk stratification. Objective To compare the… read more here.
Keywords: chronic graft; disease; skin score; bsa ... See more keywords
Patient‐reported symptom burden and impact on daily activities in chronic graft‐versus‐host disease
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5209
Abstract: Chronic graft‐versus‐host disease (GVHD) is a potentially life‐threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT) treatment for hematologic malignancies. There are limited patient‐reported data concerning symptom burden and effects on activities of daily living… read more here.
Keywords: symptom burden; chronic graft; patient reported; host disease ... See more keywords
Hyperspectral imaging to accurately segment skin erythema and hyperpigmentation in cutaneous chronic graft-versus-host disease.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biophotonics"
DOI: 10.1002/jbio.202300009
Abstract: In 15 patients with the inflammatory skin condition chronic graft-versus-host-disease, hyperspectral imaging accurately delineated active erythema and post-inflammatory hyperpigmentation. The method was validated by dermatologist-approved confident delineations of only definitely affected and definitely unaffected areas… read more here.
Keywords: chronic graft; disease; hyperspectral imaging; hyperpigmentation ... See more keywords
Oral chronic graft-versus-host disease: What the general dental practitioner needs to know.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Dental Association"
DOI: 10.1016/j.adaj.2020.08.001
Abstract: BACKGROUND Long-term survivors of allogeneic hematopoietic cell transplantation will increasingly seek care from dental providers. METHODS The authors highlight the importance of minimizing oral symptoms and complications associated with oral chronic graft-versus-host-disease (cGVHD). RESULTS Chronic… read more here.
Keywords: cgvhd; versus host; oral chronic; host disease ... See more keywords
Preclinical evaluation of JAK1/2 inhibition by ruxolitinib in a murine model of chronic graft-versus-host disease.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental hematology"
DOI: 10.1016/j.exphem.2021.03.004
Abstract: The objective of this study was to examine the therapeutic effect of ruxolitinib, an orally administered selective Janus Kinase (JAK) 1/2 inhibitor, on chronic graft-versus-host disease (cGVHD) using a murine model of sclerodermatous GVHD (scl-GVHD).… read more here.
Keywords: ruxolitinib; versus host; murine model; host disease ... See more keywords
Expansion of circulating extrafollicular helper T-like cells in patients with chronic graft-versus-host disease.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2019.03.006
Abstract: Chronic graft-versus-host disease (cGVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Previous studies have shown that T follicular helper cells (Tfh) contribute to immune pathology in cGVHD,… read more here.
Keywords: extrafollicular helper; like cells; cells patients; extrafollicular like ... See more keywords
A strategy to purify, expand and gene-mark regulatory T cells (tregs) for use in the treatment of chronic Graft-Versus-Host Disease (GVHD)
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.04.026
Abstract: Background & Aim Chronic Graft-Versus-Host Disease (GVHD) is a major complication of bone marrow transplantation. Regulatory T cells (Tregs) have been shown to ameliorate GVHD in pre-clinical studies and early phase clinical trials. However, Treg… read more here.
Keywords: chronic graft; gvhd; host disease; gene ... See more keywords
Chronic graft versus host disease presenting as lichen planus pigmentosus
Sign Up to like & getrecommendations! Published in 2018 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-018-0110-z
Abstract: Chronic graft-versus-host-disease (cGVHD) is a frequent and severe complication of allogeneic hematopoietic stem cell transplantation (AHSCT). According to the National Institutes of Health, diagnostic clinical features of cGVHD include poikiloderma, lichen planus-like eruption, deep sclerotic… read more here.
Keywords: versus host; skin; planus; lichen planus ... See more keywords
Prospective evaluation of sequential treatment of sclerotic chronic graft versus host disease with rituximab and nilotinib
Sign Up to like & getrecommendations! Published in 2018 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-018-0158-9
Abstract: Sclerotic chronic graft vs. host disease (cGVHD) still has a large impact on morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). We performed the first prospective study to test whether sequential therapy of… read more here.
Keywords: sclerotic chronic; treatment; sequential treatment; host disease ... See more keywords
Delayed administration of ixazomib modifies the immune response and prevents chronic graft-versus-host disease
Sign Up to like & getrecommendations! Published in 2021 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-021-01452-1
Abstract: In this study, we aimed to modify the immune response in the long term after allogeneic bone marrow transplantation (allo-BMT) by using the proteasome inhibitor ixazomib (IXZ) at the late stages of the post-transplant period.… read more here.
Keywords: chronic graft; graft versus; immune response;
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00880-2
Abstract: Chronic graft-versus-host disease (cGVHD) is an autoimmune-like syndrome mediated by pathogenic CD4+ T and B cells, but the function of extrafollicular and germinal center CD4+ T and B interactions in cGVHD pathogenesis remains largely unknown.… read more here.
Keywords: cgvhd; versus host; cd4 interactions; chronic graft ... See more keywords