Reduced risk of chronic GVHD by low-dose rATG in adult matched sibling donor peripheral blood stem cell transplantation for hematologic malignancies
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DOI: 10.1007/s00277-019-03884-8
Abstract: The optimal rabbit anti-thymocyte globulin (rATG) graft-versus-host disease (GVHD) prophylaxis regimen in matched sibling donor peripheral blood stem cell transplantation (MSD-PBSCT) remains to be elucidated. In this prospective study, we used low-dose rATG for GVHD… read more here.
Keywords: ratg; transplantation; sibling donor; gvhd ... See more keywords
Invasive fungal disease is associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplant: a single center, retrospective study
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DOI: 10.1007/s15010-018-01265-3
Abstract: BackgroundInvasive fungal disease (IFD) and graft-versus-host disease (GVHD) are major causes of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the impacts of IFD on chronic GVHD remain unknown.MethodsWe conducted a retrospective… read more here.
Keywords: fungal disease; disease; versus; versus 001 ... See more keywords
FLT3 ligand plasma levels have no impact on outcomes after allotransplant in acute leukemia.
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DOI: 10.1016/j.cyto.2019.04.015
Abstract: OBJECTIVE This study was designed to assess the impact on outcomes of early soluble Fms-like tyrosine kinase 3 ligand concentrations (sFLc) in patients receiving an allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute lymphoblastic leukemia… read more here.
Keywords: allo hsct; acute; impact outcomes; leukemia ... See more keywords
Impact of anti-thymocyte globulin on results of allogeneic peripheral blood stem cell transplantation for patients with Philadelphia-positive acute lymphoblastic leukaemia: An analysis by the Acute Leukemia Working Party of the EBMT.
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DOI: 10.1016/j.ejca.2018.11.003
Abstract: BACKGROUND Anti-thymocyte globulin (ATG) is widely used to prevent graft-versus-host disease (GVHD) after allogeneic peripheral blood stem cell transplantation (alloPBSCT). The goal of this study was to retrospectively assess the effect of ATG on outcomes… read more here.
Keywords: anti thymocyte; risk; acute; thymocyte globulin ... See more keywords
Clinical management of genital chronic GvHD
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DOI: 10.1038/bmt.2016.315
Abstract: Chronic GvHD (cGvHD) of the genital tract is an underreported and infrequently recognized complication of allogeneic hematopoietic cell transplantation in both male and female long-term survivors. Its pathophysiology, clinical manifestations and management are not well… read more here.
Keywords: management genital; genital chronic; management; clinical management ... See more keywords
More chronic GvHD and non-relapse mortality after peripheral blood stem cell compared with bone marrow in hematopoietic transplantation for paediatric acute lymphoblastic leukemia: a retrospective study on behalf of the EBMT Paediatric Diseases Working Party
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DOI: 10.1038/bmt.2017.66
Abstract: More chronic GvHD and non-relapse mortality after peripheral blood stem cell compared with bone marrow in hematopoietic transplantation for paediatric acute lymphoblastic leukemia: a retrospective study on behalf of the EBMT Paediatric Diseases Working Party read more here.
Keywords: bone; transplantation; gvhd non; chronic gvhd ... See more keywords
Analysis of BMT CTN-0201 and -0901 samples did not reproduce the reported association between recipient REG3A rs7588571 and chronic GVHD
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DOI: 10.1038/s41409-018-0331-1
Abstract: Regenerating islet-derived protein 3 alpha (REG3A) is a C-type lectin constitutively expressed and apically secreted by Paneth cells at high levels, with powerful bactericidal activity against gram-positive bacteria of the gut [1]. By limiting the… read more here.
Keywords: bmt ctn; ctn 0201; association; gvhd ... See more keywords
Similar incidence of severe acute GVHD and less severe chronic GVHD in PBSCT from unmanipulated, haploidentical donors compared with that from matched sibling donors for patients with haematological malignancies
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DOI: 10.1111/bjh.14331
Abstract: The features of graft‐versus‐host disease (GVHD) were compared between patients who underwent myeloablative conditioning and received a peripheral blood stem cell transplant (PBSCT) from either a haploidentical donor (HID) or a matched sibling donor (MSD)… read more here.
Keywords: acute gvhd; group; gvhd; pbsct ... See more keywords
Graft‐versus‐host disease and graft‐versus‐leukaemia effects in secondary acute myeloid leukaemia: a retrospective, multicentre registry analysis from the Acute Leukaemia Working Party of the EBMT
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DOI: 10.1111/bjh.16185
Abstract: We assessed the susceptibility of secondary acute myeloid leukaemia (sAML) to graft‐versus‐leukaemia effects. Data from 2414 sAML patients in first (n = 2194) or second (n = 220) complete remission were included. They were given… read more here.
Keywords: versus leukaemia; leukaemia; graft versus; chronic gvhd ... See more keywords
Silver Lining: Reduced Relapse with Chronic GVHD after Transplant for MDS
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DOI: 10.1158/1078-0432.ccr-20-3583
Abstract: Chronic GVHD following hematopoietic cell transplantation is associated with reduced relapse incidence in patients with leukemias. This impact has been investigated in myelodysplastic syndrome, showing a beneficial impact of limited chronic GVHD on transplant outcomes… read more here.
Keywords: chronic gvhd; gvhd; silver lining; reduced relapse ... See more keywords
Classification systems for chronic graft-versus-host disease.
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DOI: 10.1182/blood-2016-07-686642
Abstract: Chronic graft versus host disease (GVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation. Clinically, chronic GVHD is a pleiotropic, multiorgan syndrome involving tissue inflammation and fibrosis that often results… read more here.
Keywords: versus host; host; chronic graft; graft versus ... See more keywords