Design of TLR2-ligand-synthetic long peptide conjugates for therapeutic vaccination of chronic HBV patients.
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral research"
DOI: 10.1016/j.antiviral.2020.104746
Abstract: Synthetic long peptide (SLP) vaccination is a promising new treatment strategy for patients with a chronic hepatitis B virus (HBV) infection. We have previously shown that a prototype HBV-core protein derived SLP was capable of… read more here.
Keywords: chronic hbv; synthetic long; tlr2 ligand; slp ... See more keywords
Multi-parametric analysis of human livers reveals variation in intrahepatic inflammation across phases of chronic hepatitis B infection.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2022.02.016
Abstract: BACKGROUND AND AIMS Chronic HBV is clinically defined in 4 phases by a combination of serum HBV DNA levels, HBeAg status and ALT: immunotolerant (IT), immune-active (IA), inactive carrier (IC) and HBeAg-negative hepatitis (ENEG). Immune… read more here.
Keywords: chronic hbv; parametric analysis; analysis human; human livers ... See more keywords
Cryptolepine and Nibima inhibit hepatitis B virus replication
Sign Up to like & getrecommendations! Published in 2021 at "Scientific African"
DOI: 10.1016/j.sciaf.2021.e00942
Abstract: Abstract The continuous use of interferons (IFNs) in patients with chronic hepatitis B virus (HBV) infection leads to myriad adverse effects. Also, in sub-Saharan Africa where chronic HBV infection is endemic, pegylated IFN-α and tenofovir… read more here.
Keywords: chronic hbv; hbv; cryptolepine; hepatitis virus ... See more keywords
Viral infections: Reinvigorating exhausted T cells in hepatitis B infection
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Immunology"
DOI: 10.1038/nri.2017.35
Abstract: hepatitis B virus (HBV), T cells become exhausted, and their antiviral response is weakened. An article in Nature Medicine now shows that reducing mitochondrial dysfunction using mitochondrion-targeted antioxidants in CD8+ T cells from patients with… read more here.
Keywords: chronic hbv; function; infection; cells patients ... See more keywords
Tenofovir is Associated With Lower Risk of Hepatocellular Carcinoma Than Entecavir in Patients With Chronic HBV Infection in China.
Sign Up to like & getrecommendations! Published in 2019 at "Gastroenterology"
DOI: 10.1053/j.gastro.2019.09.025
Abstract: BACKGROUND & AIMS There have been conflicting results from studies comparing the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection treated with tenofovir disoproxil fumarate (TDF) vs those treated… read more here.
Keywords: chronic hbv; risk; treatment; patients chronic ... See more keywords
Recent advances in the discovery and development of TLR ligands as novel therapeutics for chronic HBV and HIV infections
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2018.1473372
Abstract: ABSTRACT Introduction: Toll-like receptor (TLR) ligands remain as promising antiviral drug candidates for the treatment of chronic viral infections. Basic research on the mechanisms of antiviral activity of TLR ligands in preclinical animal models and… read more here.
Keywords: tlr ligands; chronic hbv; hiv; tlr ... See more keywords
2194. Hepatitis B Care Cascade Within the VA Maryland Healthcare System
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy210.1848
Abstract: Abstract Background Approximately 730,000 Americans are estimated to have chronic hepatitis B (HBV) infection, but recent studies have identified gaps in HBV care. Our aim is to characterize the HBV care cascade at the Veterans… read more here.
Keywords: chronic hbv; hepatitis; hbv; hbv infection ... See more keywords
Mortality and cause of death in persons with chronic hepatitis B virus infection versus healthy persons from the general population in Denmark
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Viral Hepatitis"
DOI: 10.1111/jvh.13713
Abstract: The study aimed to determine adjusted all‐cause mortality and cause of death in persons with chronic hepatitis B virus (HBV) infection compared with age‐ and sex‐matched persons from the general population. We used nationwide registers… read more here.
Keywords: hbv infection; infection; persons chronic; death ... See more keywords
Impact of in vitro fertilization‐embryo transfer on mother‐to‐infant transmission in women with chronic HBV infection
Sign Up to like & getrecommendations! Published in 2022 at "Liver International"
DOI: 10.1111/liv.15349
Abstract: In vitro fertilization‐embryo transfer (IVF‐ET) may increase the risk of mother‐to‐child transmission (MTCT) of hepatitis B virus (HBV). The purpose of this study was to investigate the impact and safety of IVF‐ET on MTCT in… read more here.
Keywords: hbv infection; vitro fertilization; embryo transfer; chronic hbv ... See more keywords
Burden and impacts of chronic hepatitis B infection in rural Senegal: study protocol of a cross-sectional survey in the area of Niakhar (AmBASS ANRS 12356)
Sign Up to like & getrecommendations! Published in 2019 at "BMJ Open"
DOI: 10.1136/bmjopen-2019-030211
Abstract: Introduction Though Senegal has one of the highest estimated prevalence rates of chronic hepatitis B virus (HBV) infection worldwide, epidemiological data in the general population are lacking and consequences of the infection remain undocumented. The… read more here.
Keywords: chronic hbv; hbv; infection; study ... See more keywords
Veritable antiviral capacity of natural killer cells in chronic HBV infection: an argument for an earlier anti-virus treatment
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-017-1318-1
Abstract: BackgroundThere is limited information on innate immunity, especially natural killer (NK) cell function, in different chronic hepatitis B (CHB) stages. Therefore, we examined whether the clinical staging strategy accurately reflects veritable NK cell immunity.MethodsA total… read more here.
Keywords: chronic hbv; chb; function; treatment ... See more keywords