Patient‐shared TCRβ‐CDR3 clonotypes correlate with favorable prognosis in chronic hepatitis B
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DOI: 10.1002/eji.201747327
Abstract: The presence of shared T‐cell clonotypes was found in several different diseases, but its relationship with the progression of disease remains unclear. By sequencing the complementary determining region 3 of T‐cell receptor (TCR) β chains… read more here.
Keywords: favorable prognosis; patient shared; chronic hepatitis; shared tcr ... See more keywords
Autoimmune‐like chronic hepatitis induced by olmesartan
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DOI: 10.1002/hep.29228
Abstract: Drug liver-induced injury (DILI) attributed to minocyclin, alpha methyldopa, or nitrofurantoin may be responsible for chronic liver damage that mimics the biological and/or histological features of chronic autoimmune hepatitis and, in rare cases, progresses to… read more here.
Keywords: induced olmesartan; like chronic; hepatitis; autoimmune like ... See more keywords
Risk stratification of hepatic encephalopathy in liver cirrhosis patients: Novel strategy with novel concerns
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DOI: 10.1002/hep.29747
Abstract: 1) Choi J, Han S, Kim N, Lim YS. Increasing burden of liver cancer despite extensive use of antiviral agents in a hepatitis B virusendemic population. HEPATOLOGY 2017;66:1454-1463. 2) Su TH, Hu TH, Chen CY,… read more here.
Keywords: risk stratification; stratification hepatic; liver; chronic hepatitis ... See more keywords
The Efficacy of Tenofivir to Prevent Perinatal Transmission in Chronic Hepatitis B Mothers. A Clinical Perspective
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DOI: 10.1002/hep.30138
Abstract: With great satisfaction, we read The April, 2018 AASLD guidelines for the management of chronic hepatitis B propose that pregnant women with hepatitis B receive tenofovir in the third trimester, for viral loads greater than… read more here.
Keywords: hepatitis; prevent perinatal; efficacy tenofivir; perinatal transmission ... See more keywords
Nonalcoholic Steatohepatitis Is Associated With Liver‐Related Outcomes and All‐Cause Mortality in Chronic Hepatitis B
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DOI: 10.1002/hep.30857
Abstract: Chronic hepatitis B (CHB) and nonalcoholic fatty liver disease are increasingly observed together in clinical practice, and development of nonalcoholic steatohepatitis (NASH) represents another leading cause of liver‐related morbidity and mortality. Our aims were to… read more here.
Keywords: nonalcoholic steatohepatitis; mortality; liver related; chronic hepatitis ... See more keywords
Letter to the Editor: Chronic Hepatitis B and Nonalcoholic Steatohepatitis: Is “Fat” All Bad?
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DOI: 10.1002/hep.30983
Abstract: We read with interest the recent paper by Choi et al.(1) on the impact of biopsy-proven nonalcoholic steatohepatitis (NASH) on chronic hepatitis B (CHB) outcomes. The study concluded that compared to patients with CHB alone,… read more here.
Keywords: chronic hepatitis; chb; advanced fibrosis; nonalcoholic steatohepatitis ... See more keywords
Low Incidence of Adverse Outcomes in Adults With Chronic Hepatitis B Virus Infection in the Era of Antiviral Therapy
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DOI: 10.1002/hep.31554
Abstract: Outcomes of persons with chronic hepatitis B virus (HBV) infection in the era of antiviral therapy (AVT) are not well characterized. We determined the incidence and factors associated with clinical outcomes in a multiethnic, North… read more here.
Keywords: era antiviral; antiviral therapy; infection era; infection ... See more keywords
Association of Metabolic Risk Factors With Risks of Cancer and All‐Cause Mortality in Patients With Chronic Hepatitis B
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DOI: 10.1002/hep.31612
Abstract: Long‐term antiviral therapy can effectively suppress viral replication and improve clinical outcomes in patients with chronic hepatitis B (CHB), but it cannot eliminate risk of HCC. We investigated the association of metabolic risk factors with… read more here.
Keywords: risk; metabolic risk; risk factors; patients chronic ... See more keywords
Safety, Pharmacokinetics, and Pharmacodynamics of the Oral TLR8 Agonist Selgantolimod in Chronic Hepatitis B
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DOI: 10.1002/hep.31795
Abstract: In patients with chronic hepatitis B (CHB) infection, activation of toll‐like receptor 8 may induce antiviral immunity and drive functional cure. Selgantolimod, a toll‐like receptor 8 agonist, was evaluated in patients with CHB who were… read more here.
Keywords: chronic hepatitis; hepatitis; agonist; pharmacokinetics pharmacodynamics ... See more keywords
Letter to the Editor: Use of New Defined Metabolic Risk Factors in Patients with Chronic Hepatitis B - The Authors' reply.
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DOI: 10.1002/hep.31844
Abstract: We thank Dr. Liu et al for their interest and the comments about our article.(1) In our current study, we validated an association of the burden of metabolic risk factors with risks of hepatocellular carcinoma… read more here.
Keywords: metabolic risk; patients chronic; risk factors; chronic hepatitis ... See more keywords
PD-1 Expressing CD8+CXCR5+ Follicular T Cells Constitute Effector Rather Than Exhaustive Phenotype in Patients with Chronic Hepatitis B.
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DOI: 10.1002/hep.32210
Abstract: Classical CD8 T cells are implicated for protective and pathogenic roles in chronic hepatitis B(CHB) infection. Recently, a new subset of CD8 T cells expressing CXCR5 and exhibiting features of TFH cells has been identified… read more here.
Keywords: hbsag hbv; cxcr5; cxcr5 cells; chronic hepatitis ... See more keywords