Using RNA-seq as an unbiased approach to identify adaptive responses to mild vs. moderate chronic hypercapnia in goats
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DOI: 10.1152/physiol.2023.38.s1.5729935
Abstract: Chronic hypercapnia (CH, PaCO2 > 45mmHg) is commonly reported in chronic obstructive pulmonary disease (COPD). The severity of CH can increase acutely during frequent acute-on-chronic exacerbations and/or chronically as COPD progresses. We have shown (Buchholz… read more here.
Keywords: mild moderate; chronic hypercapnia; control; unbiased approach ... See more keywords
Glutamate receptor plasticity in brainstem respiratory nuclei following chronic hypercapnia in goats
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DOI: 10.14814/phy2.14035
Abstract: Patients that retain CO2 in respiratory diseases such as chronic obstructive pulmonary disease (COPD) have worse prognoses and higher mortality rates than those with equal impairment of lung function without hypercapnia. We recently characterized the… read more here.
Keywords: brainstem respiratory; chronic hypercapnia; hypercapnia; respiratory nuclei ... See more keywords
Effects of chronic hypercapnia on ammonium transport in the mouse kidney
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DOI: 10.14814/phy2.14221
Abstract: Hypercapnia and subsequent respiratory acidosis are serious complications in many patients with respiratory disorders. The acute response to hypercapnia is buffering of H+ by hemoglobin and cellular proteins but this effect is limited. The chronic… read more here.
Keywords: excretion; chronic hypercapnia; effects chronic; hypercapnia ... See more keywords