The transition between acute and chronic infections in light of energy control: a mathematical model of energy flow in response to infection
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2022.0206
Abstract: Background: Different parts of an organism like the gut, endocrine, nervous and immune systems constantly exchange information. Understanding the pathogenesis of various systemic chronic diseases increasingly relies on understanding how these subsystems orchestrate their activities.… read more here.
Keywords: model energy; mathematical model; chronic infections; energy ... See more keywords
Chronic infections with viruses or parasites: breaking bad to make good
Sign Up to like & getrecommendations! Published in 2017 at "Immunology"
DOI: 10.1111/imm.12703
Abstract: Eukaryotic forms of life have been continually invaded by microbes and larger multicellular parasites, such as helminths. Over a billion years ago bacterial endosymbionts permanently colonized eukaryotic cells leading to recognized organelles with a distinct… read more here.
Keywords: bad make; breaking bad; parasites breaking; chronic infections ... See more keywords
Giving antibodies a boost
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.361.6409.1350-n
Abstract: Antibodies Persistent immune activation during chronic infections is often associated with increased generation and deposition of immune complexes. The actions of antibody-based drugs can thus be severely impaired in individuals with chronic infections. Using lymphocytic… read more here.
Keywords: antibodies boost; chronic infections; giving antibodies;
Investigation of the Mechanism and Chemistry Underlying Staphylococcus aureus' Ability to Inhibit Pseudomonas aeruginosa Growth In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00174-22
Abstract: Chronic infections affect a growing part of the population and are associated with high societal and personal costs. Multiple bacterial species are often present in these infections, and multispecies infections are considered more severe than… read more here.
Keywords: pseudomonas aeruginosa; chemistry; chronic infections; staphylococcus aureus ... See more keywords
The Role of Integration Host Factor in Escherichia coli Persister Formation
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DOI: 10.1128/mbio.03420-21
Abstract: Persisters are phenotypic variants that survive exposure to antibiotics through temporary dormancy. Mutants with increased levels of persisters have been identified in clinical isolates, and evidence suggests these cells contribute to chronic infections and antibiotic… read more here.
Keywords: persister formation; escherichia coli; integration host; chronic infections ... See more keywords
mSphere of Influence: Combining Host and Pathogen Genetics To Disrupt Chronic Infections
Sign Up to like & getrecommendations! Published in 2020 at "mSphere"
DOI: 10.1128/msphere.00106-20
Abstract: Andrew J. Olive works in the field of host responses to chronic infections. In this mSphere of Influence article, he reflects on how “Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing” (Y. J. Zhang, M.… read more here.
Keywords: host pathogen; msphere influence; chronic infections; genetics ... See more keywords
Genetic and Transcriptomic Characteristics of RhlR-Dependent Quorum Sensing in Cystic Fibrosis Isolates of Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2022 at "mSystems"
DOI: 10.1128/msystems.00113-22
Abstract: The bacterial pathogen Pseudomonas aeruginosa can cause chronic infections that are resistant to treatment in immunocompromised individuals. Over the course of these infections, the original infecting organism adapts to the host environment. P. aeruginosa uses… read more here.
Keywords: quorum sensing; cystic fibrosis; chronic infections; cell ... See more keywords
Modeling and Mathematical Analysis of the Dynamics of HPV in Cervical Epithelial Cells: Transient, Acute, Latency, and Chronic Infections
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/8650071
Abstract: The aim of this paper is to model the dynamics of the human papillomavirus (HPV) in cervical epithelial cells. We developed a mathematical model of the epithelial cellular dynamics of the stratified epithelium of three… read more here.
Keywords: dynamics hpv; transient acute; chronic infections; cervical epithelial ... See more keywords
Do Mixed-Species Biofilms Dominate in Chronic Infections?–Need for in situ Visualization of Bacterial Organization
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2020.00396
Abstract: Chronic infections present a serious economic burden to health-care systems. The severity and prevalence of chronic infections are continuously increasing due to an aging population and an elevated number of lifestyle related diseases such as… read more here.
Keywords: biofilms chronic; biofilms dominate; mixed species; species biofilms ... See more keywords
NK Cell Exhaustion
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00760
Abstract: Natural killer cells are important effector lymphocytes of the innate immune system, playing critical roles in antitumor and anti-infection host defense. Tumor progression or chronic infections, however, usually leads to exhaustion of NK cells, thus… read more here.
Keywords: cell; infection; chronic infections; biology ... See more keywords
Fast and Simple Liquid Chromatography-Isotope Dilution Tandem Mass Spectrometry Method for Therapeutic Drug Monitoring of Dalbavancin in Long-Term Treatment of Subacute and/or Chronic Infections
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020480
Abstract: Dalbavancin (DBV) is a long-acting antistaphylococcal lypoglycopeptide that is being increasingly used for long-term treatment of a wide range of subacute and/or chronic infections, mainly osteo-articular infections (OAI). Population pharmacokinetic studies showed that two 1500… read more here.
Keywords: long term; subacute chronic; chronic infections; treatment ... See more keywords