Phenotypic Screening of Prospective Analgesics Among FDA‐Approved Compounds using an iPSC‐Based Model of Acute and Chronic Inflammatory Nociception
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202303724
Abstract: Classical target‐based drug screening is low‐throughput, largely subjective, and costly. Phenotypic screening based on in vitro models is increasingly being used to identify candidate compounds that modulate complex cell/tissue functions. Chronic inflammatory nociception, and subsequent… read more here.
Keywords: phenotypic screening; nociception; model; fda approved ... See more keywords
Iron deficiency across chronic inflammatory conditions: International expert opinion on definition, diagnosis, and management
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24820
Abstract: Abstract Iron deficiency, even in the absence of anemia, can be debilitating, and exacerbate any underlying chronic disease, leading to increased morbidity and mortality. Iron deficiency is frequently concomitant with chronic inflammatory disease; however, iron… read more here.
Keywords: diagnosis; disease; chronic inflammatory; iron deficiency ... See more keywords
Quantitative muscle ultrasound is useful for evaluating secondary axonal degeneration in chronic inflammatory demyelinating polyneuropathy
Sign Up to like & getrecommendations! Published in 2017 at "Brain and Behavior"
DOI: 10.1002/brb3.812
Abstract: In chronic inflammatory demyelinating polyneuropathy (CIDP), exclusion of secondary axonal degeneration is challenging with conventional methods such as nerve conduction study (NCS), needle electromyography, and nerve biopsy. Increased echo intensity (EI) and decreased muscle thickness… read more here.
Keywords: inflammatory demyelinating; muscle; chronic inflammatory; axonal degeneration ... See more keywords
Prognosis evaluation of chronic inflammatory cardiomyopathy with ring‐like late gadolinium enhancement
Sign Up to like & getrecommendations! Published in 2023 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14334
Abstract: Ring‐like late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) imaging is a special LGE pattern in patients with chronic inflammatory cardiomyopathy (infl‐CMP), which is associated with cardiac dysfunction and ventricular remodelling and attributed to… read more here.
Keywords: inflammatory cardiomyopathy; late gadolinium; ring like; like late ... See more keywords
Validation of Chronic Inflammatory Demyelinating Polyradiculoneuropathy Coding in US Claims Data
Sign Up to like & getrecommendations! Published in 2025 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.70123
Abstract: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare autoimmune condition of the peripheral nervous system. The validity of the CIDP diagnosis code in claims data is unclear. read more here.
Keywords: validation chronic; claims data; inflammatory demyelinating; demyelinating polyradiculoneuropathy ... See more keywords
Innate lymphoid cells in autoimmunity and chronic inflammatory diseases
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-018-0670-4
Abstract: Abnormal activation of the innate immune system is a common feature of autoimmune and chronic inflammatory diseases. Since their identification as a separate family of leukocytes, innate lymphoid cells (ILCs) have emerged as important effector… read more here.
Keywords: inflammatory diseases; inflammatory; chronic inflammatory; innate lymphoid ... See more keywords
Microfibrillar-associated protein 4 as a predictive biomarker of treatment response in patients with chronic inflammatory diseases initiating biologics: secondary analyses based on the prospective BELIEVE cohort study
Sign Up to like & getrecommendations! Published in 2024 at "Rheumatology International"
DOI: 10.1007/s00296-024-05744-9
Abstract: Currently, there are no reliable biomarkers for predicting treatment response in chronic inflammatory diseases (CIDs). To determine whether serum microfibrillar-associated protein 4 (MFAP4) levels can predict the treatment response to biological therapy in patients with… read more here.
Keywords: mfap4; treatment; treatment response; response ... See more keywords
Quality of life predictors in patients with chronic inflammatory demyelinating polyradiculoneuropathy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurology"
DOI: 10.1007/s00415-017-8658-x
Abstract: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a chronic disease which can lead to many functional impairments, and like most other chronic disorders it might significantly affect quality of life (QoL). Information about QoL in patients… read more here.
Keywords: demyelinating polyradiculoneuropathy; inflammatory demyelinating; chronic inflammatory; quality life ... See more keywords
Early therapy initiation is crucial in chronic inflammatory demyelinating polyneuropathy: prospective multimodal data from the German INHIBIT registry
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neurology"
DOI: 10.1007/s00415-024-12860-w
Abstract: Diagnosing chronic inflammatory demyelinating polyneuropathy (CIDP) can be challenging, leading to delays in initiating therapy. As disability in CIDP is mainly dependent on axonal damage, the impact of delayed immunotherapy remains unclear. We multimodally investigated… read more here.
Keywords: therapy; inflammatory demyelinating; demyelinating polyneuropathy; axonal damage ... See more keywords
Amitriptyline Downregulates Chronic Inflammatory Response to Biomaterial in Mice.
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01356-0
Abstract: Recent data has signaled that in addition to its therapeutic indications as antidepressant and analgesic, amitriptyline (AM) exerts anti-inflammatory effects in humans and experimental animal models of acute inflammation. We tested the hypothesis that this… read more here.
Keywords: treatment; inflammation; chronic inflammatory; mice ... See more keywords
Analgesic Effect of Methane Rich Saline in a Rat Model of Chronic Inflammatory Pain
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2490-2
Abstract: How oxidative stress contributes to neuro-inflammation and chronic pain is documented, and methane is reported to protect against ischemia–reperfusion injury in the nervous system via anti-inflammatory and antioxidant properties. We studied whether methane in the… read more here.
Keywords: inflammatory pain; pain; methane; chronic inflammatory ... See more keywords