Spinal IL‐33/ST2 signaling mediates chronic itch in mice through the astrocytic JAK2‐STAT3 cascade
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DOI: 10.1002/glia.23639
Abstract: Interleukin‐33 (IL‐33) and its receptor ST2 contribute to spinal glial activation and chronic pain. A recent study showed that peripheral IL‐33 plays a pivotal role in the pathogenesis of chronic itch induced by poison ivy.… read more here.
Keywords: itch; spinal st2; chronic itch; st2 signaling ... See more keywords
Keratinocyte TLR2 and TLR7 contribute to chronic itch through pruritic cytokines and chemokines in mice
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DOI: 10.1002/jcp.30923
Abstract: Although neuronal Toll‐like receptors (TLRs) (e.g., TLR2, TLR3, and TLR7) have been implicated in itch sensation, the roles of keratinocyte TLRs in chronic itch are elusive. Herein, we evaluated the roles of keratinocyte TLR2 and… read more here.
Keywords: keratinocyte tlr2; tlr2 tlr7; itch; chronic itch ... See more keywords
Chronic itch in African Americans: an unmet need
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DOI: 10.1007/s00403-021-02255-6
Abstract: Chronic pruritus carries a significant burden of disease and is associated with a negative impact on quality of life. African Americans are disproportionately burdened by chronic pruritic disorders, including but not limited to atopic dermatitis,… read more here.
Keywords: americans unmet; unmet need; african americans; chronic itch ... See more keywords
Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch
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DOI: 10.1016/j.cell.2017.08.006
Abstract: Mammals have evolved neurophysiologic reflexes, such as coughing and scratching, to expel invading pathogens and noxious environmental stimuli. It is well established that these responses are also associated with chronic inflammatory diseases, including asthma and… read more here.
Keywords: signaling pathways; itch; classical immune; immune signaling ... See more keywords
Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions.
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DOI: 10.1016/j.jphs.2020.07.010
Abstract: Astrocytes are the most abundant glial cells in the central nervous system (CNS), including the spinal cord. Neuronal damage induces astrocytes to become reactive and contribute to various CNS pathologies. Recent studies have demonstrated that… read more here.
Keywords: itch; spinal dorsal; dorsal horn; itch conditions ... See more keywords
Astrocytes in the spinal dorsal horn and chronic itch
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Research"
DOI: 10.1016/j.neures.2017.08.010
Abstract: Chronic itch is a hallmark symptom of inflammatory skin conditions, such as atopic dermatitis. Existing treatment for chronic itch is largely ineffective. Despite recent progress in our understanding of the neuronal basis for itch sensation… read more here.
Keywords: itch; spinal dorsal; dorsal horn; chronic itch ... See more keywords
Central Processing of Itch in the Midbrain Reward Center
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DOI: 10.1016/j.neuron.2019.03.030
Abstract: Itch is an aversive sensation that evokes a desire to scratch. Paradoxically, scratching the itch also produces a hedonic experience. The specific brain circuits processing these different aspects of itch, however, remain elusive. Here, we report… read more here.
Keywords: itch; processing itch; itch midbrain; central processing ... See more keywords
Homeostatic pruning and activity of epidermal nerves are dysregulated in barrier-impaired skin during chronic itch development
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DOI: 10.1038/s41598-019-44866-0
Abstract: The epidermal barrier is thought to protect sensory nerves from overexposure to environmental stimuli, and barrier impairment leads to pathological conditions associated with itch, such as atopic dermatitis (AD). However, it is not known how… read more here.
Keywords: itch; epidermal nerves; skin; chronic itch ... See more keywords
The ‘Chronic Itch Burden Scale’: giving patients with chronic pruritus a voice
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DOI: 10.1111/bjd.20714
Abstract: ity of complex diseases. Nature 2009; 461:747–53. 5 Roda G, Chien Ng S, Kotze PG et al. Crohn’s disease. Nat Rev Dis Primers 2020; 6:22. 6 Giamarellos-Bourboulis EJ, Platzer M, Karagiannidis I et al. High… read more here.
Keywords: hidradenitis; chronic itch; hidradenitis suppurativa; burden scale ... See more keywords
Generalized chronic itch induced by small‐fibre neuropathy: clinical profile and proposed diagnostic criteria
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DOI: 10.1111/jdv.16151
Abstract: Small‐fibre neuropathy (SFN) is a known cause for pain, however, it may be also associated with chronic itch. The clinical profile of chronic itch due to SFN is poorly defined and accordingly under‐diagnosed in clinical… read more here.
Keywords: itch; fibre neuropathy; small fibre; chronic itch ... See more keywords
Characterization of chronic itch in college students in China
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DOI: 10.1684/ejd.2022.4193
Abstract: Background Chronic itch affects a et al. range of individuals and has a noticeable influence on human health. However, epidemiological characteristics of chronic itch have not yet been adequately addressed. Objectives To investigate the prevalence… read more here.
Keywords: college students; behavioural factors; itch; chronic itch ... See more keywords