STAT3 mutations in natural killer cells are associated with cytopenia in patients with chronic lymphoproliferative disorder of natural killer cells
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DOI: 10.1007/s12185-019-02625-x
Abstract: Chronic lymphoproliferative disorder of natural killer (NK) cells (CLPD-NK) is a rare disease with an indolent clinical course, which is characterized by persistent increase in large granular lymphocytes of NK-cell type. A somatic mutation in… read more here.
Keywords: killer cells; natural killer; chronic lymphoproliferative; lymphoproliferative disorder ... See more keywords
A high definition picture of somatic mutations in chronic lymphoproliferative disorder of natural killer cells
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DOI: 10.1038/s41408-020-0309-2
Abstract: The molecular pathogenesis of chronic lymphoproliferative disorder of natural killer (NK) cells (CLPD‐NK) is poorly understood. Following the screening of 57 CLPD-NK patients, only five presented STAT3 mutations. WES profiling of 13 cases negative for… read more here.
Keywords: natural killer; somatic mutations; chronic lymphoproliferative; lymphoproliferative disorder ... See more keywords
Germline Gain-of-Function JAK3 Mutation in Familial Chronic Lymphoproliferative Disorder of NK Cells
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DOI: 10.1182/blood-2020-142078
Abstract: Chronic lymphoproliferative disorder of NK-cells (CLPD-NK) predominantly occurs in adults with a median age of diagnosis at 60 years. It is characterized by a persistent increase (≥2 x 109/L, for > 6 months) of mature… read more here.
Keywords: jak3; gof; disorder; chronic lymphoproliferative ... See more keywords
Linking the KIR phenotype with STAT3 and TET2 mutations to identify chronic lymphoproliferative disorders of NK cells.
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DOI: 10.1182/blood.2020006721
Abstract: Distinguishing chronic lymphoproliferative disorders of NK cells (CLPD-NK) from reactive NK cell expansions is challenging. We assessed the value of NK receptor phenotyping and targeted high-throughput sequencing in a cohort of 114 consecutive patients with… read more here.
Keywords: stat3 tet2; tet2 mutations; disorders cells; lymphoproliferative disorders ... See more keywords
Pulmonary infiltration as the initial manifestation of chronic lymphoproliferative disorder of natural killer cells: a case report and literature review
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DOI: 10.1186/s12890-021-01457-y
Abstract: Background Chronic lymphoproliferative disorder of natural killer cells (CLPD-NK) is an extremely rare haematological disease. To the best of our knowledge, pulmonary infiltration in CLPD-NK has not been reported before. Our case study aimed to… read more here.
Keywords: pulmonary infiltration; case; lymphoproliferative disorder; chronic lymphoproliferative ... See more keywords