Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis
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DOI: 10.1007/s00213-017-4720-8
Abstract: RationaleSaikosaponin D (SSD), a major bioactive component isolated from Radix Bupleuri, has been reported to exert neuroprotective properties.ObjectivesThe present study was designed to investigate the anti-depressant-like effects and the potential mechanisms of SSD.MethodsBehavioural tests including… read more here.
Keywords: hippocampal neurogenesis; unpredictable chronic; chronic mild; hpa axis ... See more keywords
Depressive- and anxiety-like phenotypes in young adult APPSwe/PS1dE9 transgenic mice with insensitivity to chronic mild stress
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.07.007
Abstract: HIGHLIGHTSDepressive‐like and anxiety‐like symptoms in 16‐week‐old APP/PS1 mice.APP/PS1 mice showed low levels of serum corticosterone.Chronic mild stress aggravated anxiety‐like behaviors, but not depressive‐like behaviors of APP/PS1 mice.CMS caused more severe neuroinflammation of APP/PS1 mice. ABSTRACT… read more here.
Keywords: anxiety like; chronic mild; appswe ps1de9; mice ... See more keywords
Antidepressant-like effects of ginsenoside Rg2 in a chronic mild stress model of depression
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2017.08.009
Abstract: Major depression is a common neuropsychiatric disease with high lifetime prevalence and high incidence of suicide. This study aimed to evaluate the antidepressant effects of ginsenoside Rg2 in mice, and the possible mechanism was also… read more here.
Keywords: effects ginsenoside; like effects; chronic mild; mild stress ... See more keywords
Sex-dependent influence of chronic mild stress (CMS) on voluntary alcohol consumption; study of neurobiological consequences
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2016.11.005
Abstract: ABSTRACT Alcohol use disorder and depression are highly comorbid, and both conditions exhibit important sexual dimorphisms. Here, we aimed to investigate voluntary alcohol consumption after 6 weeks of chronic mild stress (CMS) in Wistar rats… read more here.
Keywords: voluntary alcohol; alcohol consumption; cms; chronic mild ... See more keywords
The chronic mild stress (CMS) model of depression: History, evaluation and usage
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2016.08.002
Abstract: Now 30 years old, the chronic mild stress (CMS) model of depression has been used in >1300 published studies, with a year-on-year increase rising to >200 papers in 2015. Data from a survey of users… read more here.
Keywords: model; stress; chronic mild; cms model ... See more keywords
Improvement of penile neurogenic and endothelial relaxant responses by chronic administration of resveratrol in rabbits exposed to unpredictable chronic mild stress
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Impotence Research"
DOI: 10.1038/s41443-018-0016-8
Abstract: Chronic stress is an important public health problem known as a risk factor for depression, cognitive deficits, and also erectile dysfunction (ED). Resveratrol, a plant polyphenol, was reported to activate constitutive endothelial nitric oxide synthase… read more here.
Keywords: resveratrol; endothelium dependent; stress; chronic mild ... See more keywords
Telmisartan Activates PPARδ to Improve Symptoms of Unpredictable Chronic Mild Stress-Induced Depression in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14265-4
Abstract: Major depression is a common mental disorder that has been established to be associated with a decrease in serotonin and/or serotonin transporters in the brain. Peroxisome proliferator-activated receptor δ (PPARδ) has been introduced as a… read more here.
Keywords: ppar; depression; telmisartan; stress ... See more keywords
Preventive impacts of vitamin C on memory damage caused by unpredictable chronic mild stress in relation to biochemical parameters in the hippocampus of male rats.
Sign Up to like & getrecommendations! Published in 2022 at "Nutritional neuroscience"
DOI: 10.1080/1028415x.2022.2145423
Abstract: KEY POINTS Memory and learning impairments were induced by unpredictable chronic mild stress (UCMS)Vitamin C could prevent cognitive impairments caused by UCMS in rats by attenuation of oxidative stress in the brain. read more here.
Keywords: stress; chronic mild; mild stress; unpredictable chronic ... See more keywords
Subfield‐specific effects of chronic mild unpredictable stress on hippocampal astrocytes
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15234
Abstract: Major depressive disorder (MDD) is a debilitating neuropsychiatric illness affecting over 20% of the population worldwide. Despite its prevalence, our understanding of its pathophysiology is severely limited, thus hampering the development of novel therapeutic strategies.… read more here.
Keywords: mild unpredictable; unpredictable stress; stress; chronic mild ... See more keywords
Neuronal substrates underlying stress resilience and susceptibility in rats
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DOI: 10.1371/journal.pone.0179434
Abstract: Background Stress and stressful life events have repeatedly been shown as causally related to depression. The Chronic Mild Stress rat model is a valid model of stress-induced depression. Like humans, rats display great heterogeneity in… read more here.
Keywords: response; stress resilient; stress induced; stress ... See more keywords
Executive function and relation to static balance metrics in chronic mild TBI: A LIMBIC-CENC secondary analysis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.906661
Abstract: Introduction Among patients with traumatic brain injury (TBI), postural instability often persists chronically with negative consequences such as higher fall risk. One explanation may be reduced executive function (EF) required to effectively process, interpret and… read more here.
Keywords: function; chronic mild; executive function; balance ... See more keywords