A 1H NMR spectroscopic metabolomic study of the protective effects of irbesartan in a rat model of chronic mountain sickness.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2021.114235
Abstract: Chronic mountain sickness (CMS) is a significant pathology in most high-altitude regions globally, affecting the cardiopulmonary system and its mechanism is largely unknown. A metabonomic approach using 1H nuclear magnetic resonance spectroscopy allows for detecting… read more here.
Keywords: mountain sickness; rat model; cms; chronic mountain ... See more keywords
Cardiac remodelling in the highest city in the world: Effects of altitude and chronic mountain sickness.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of preventive cardiology"
DOI: 10.1093/eurjpc/zwac166
Abstract: AIMS A unique Andean population lives in the highest city of the world (La Rinconada, 5,100 m, Peru) and frequently develops a maladaptive syndrome, termed chronic mountain sickness (CMS). Both extreme altitude and CMS are a… read more here.
Keywords: city world; highest city; cms; chronic mountain ... See more keywords
Putatively adaptive missense variant at Adrenergic Receptor Alpha-1A associated with decreased risk of Chronic Mountain Sickness in Andean highlanders
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5735177
Abstract: Andean highlanders living at high altitude (>4200 m) for hundreds of generations exhibit distinct cardiovascular and ventilatory traits in response to environmental stress. Adrenergic Receptor Alpha-1A ( ADRA1A), a gene coding for the Alpha 1-A… read more here.
Keywords: mountain sickness; putatively adaptive; andean highlanders; physiology ... See more keywords
Pulmonary arterial pressure at rest and during exercise in chronic mountain sickness: a meta-analysis
Sign Up to like & getrecommendations! Published in 2019 at "European Respiratory Journal"
DOI: 10.1183/13993003.02040-2018
Abstract: Up to 10% of the more than 140 million high-altitude dwellers worldwide suffer from chronic mountain sickness (CMS). Patients suffering from this debilitating problem often display increased pulmonary arterial pressure (PAP), which may contribute to… read more here.
Keywords: mountain sickness; chronic mountain; rest; exercise ... See more keywords