Locus coeruleus neurons are most sensitive to chronic neuroinflammation-induced neurodegeneration
Sign Up to like & getrecommendations! Published in 2020 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.01.003
Abstract: Parkinson's disease (PD) develops over decades through spatiotemporal stages that ascend from the brainstem to the forebrain. The mechanism behind this caudo-rostral neurodegeneration remains largely undefined. In unraveling this phenomenon, we recently developed a lipopolysaccharide… read more here.
Keywords: coeruleus neurons; lps; neurodegeneration; locus coeruleus ... See more keywords
Electroconvulsive stimulation attenuates chronic neuroinflammation
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.137028
Abstract: Electroconvulsive therapy is highly effective in resistant depression by unknown mechanisms. Microglial toxicity was suggested to mediate depression and plays key roles in neuroinflammatory and degenerative diseases, where there is critical shortage in therapies. We… read more here.
Keywords: microglial neurotoxicity; electroconvulsive stimulation; neuroinflammation; ecs ... See more keywords
Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-021-02325-6
Abstract: Microglia are integral mediators of innate immunity within the mammalian central nervous system. Typical microglial responses are transient, intending to restore homeostasis by orchestrating the removal of pathogens and debris and the regeneration of damaged… read more here.
Keywords: chronic neuroinflammation; neuroinflammation; signaling microglia; kinase ... See more keywords
Cholinergic Modulation of Glial Function During Aging and Chronic Neuroinflammation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.577912
Abstract: Aging is a complex biological process that increases the risk of age-related cognitive degenerative diseases such as dementia, including Alzheimer’s disease (AD), Lewy Body Dementia (LBD), and mild cognitive impairment (MCI). Even non-pathological aging of… read more here.
Keywords: anti inflammatory; aging chronic; neuroinflammation; function ... See more keywords