An Injectable Hydrogel for Treatment of Chronic Neuropathic Pain.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202100529
Abstract: Current treatments for chronic neuropathic pain often fall short. A small-molecular compound ZL006 can suppress N-Methyl-D-aspartate receptor (NMDAR)-mediated neuropathic pain behaviors without blocking essential NMDAR function and brings new hope for neuropathic pain therapy. The… read more here.
Keywords: injectable hydrogel; zl006; pain; neuropathic pain ... See more keywords
[Pharmacotherapy of chronic neuropathic pain].
Sign Up to like & getrecommendations! Published in 2019 at "Der Internist"
DOI: 10.1007/s00108-019-0627-2
Abstract: Chronic neuropathic pain has a prevalence of 6.9-10% in the general population. The current recommendations for treatment are presented based on a literature search. Neuropathic pain requires the use of co-analgesic, antidepressant, anticonvulsant drugs and topical agents… read more here.
Keywords: chronic neuropathic; etiology; pharmacotherapy chronic; neuropathic pain ... See more keywords
Repetitive Transcranial Magnetic Stimulation for Treating Chronic Neuropathic Pain: a Systematic Review
Sign Up to like & getrecommendations! Published in 2021 at "Current Pain and Headache Reports"
DOI: 10.1007/s11916-021-00960-5
Abstract: Given pharmacological interventions’ limited efficacy and abundance of its adverse effects, the repetitive transcranial magnetic stimulation (rTMS) is considered a viable non-invasive option for managing chronic neuropathic pain of different origins with promising outcomes. The… read more here.
Keywords: chronic neuropathic; stimulation; repetitive transcranial; transcranial magnetic ... See more keywords
The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0492-8
Abstract: Chronic neuropathic pain (CNP) is one of the most significant unmet clinical needs in modern medicine. Alongside the lack of effective treatments, there is a great deficit in the availability of objective diagnostic methods to… read more here.
Keywords: chronic neuropathic; diagnosis; translational biomarkers; neuropathic pain ... See more keywords
Cannabis-Based Medicines and Medical Cannabis for Chronic Neuropathic Pain
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DOI: 10.1007/s40263-021-00879-w
Abstract: Neuropathic pain represents a broad category of pain syndromes that include a wide variety of peripheral and central disorders. The overall prevalence of neuropathic pain in the general population is reported to be between 7… read more here.
Keywords: chronic neuropathic; cannabis based; based medicines; neuropathic pain ... See more keywords
Efficacy of Internet-Delivered Mindfulness for Improving Depression in Caregivers of People With Spinal Cord Injuries and Chronic Neuropathic Pain: A Randomized Controlled Feasibility Trial.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of physical medicine and rehabilitation"
DOI: 10.1016/j.apmr.2018.08.182
Abstract: OBJECTIVES To explore the feasibility and efficacy of web-based mindfulness training for carers of people with spinal cord injury (SCI). DESIGN Randomized controlled feasibility study with 3-month follow-up. SETTING Community setting. PARTICIPANTS Spouses or family… read more here.
Keywords: chronic neuropathic; caregivers people; feasibility; neuropathic pain ... See more keywords
Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.109936
Abstract: Summary Depression symptoms are often found in patients suffering from chronic pain, a phenomenon that is yet to be understood mechanistically. Here, we systematically investigate the cellular mechanisms and circuits underlying the chronic-pain-induced depression behavior.… read more here.
Keywords: chronic neuropathic; depression; tegmental area; ventral tegmental ... See more keywords
Time course of the response to navigated repetitive transcranial magnetic stimulation at 10 Hz in chronic neuropathic pain
Sign Up to like & getrecommendations! Published in 2018 at "Neurological Research"
DOI: 10.1080/01616412.2018.1453636
Abstract: ABSTRACT Objective This prospective study evaluated the time to response and outcomes of navigated repetitive transcranial magnetic stimulation (TMS) at a frequency of 10 Hz in patients with chronic neuropathic pain. Methods This prospective study… read more here.
Keywords: chronic neuropathic; stimulation; navigated repetitive; time ... See more keywords
Intrathecal injection of dexmedetomidine ameliorates chronic neuropathic pain via the modulation of MPK3/ERK1/2 in a mouse model of chronic neuropathic pain
Sign Up to like & getrecommendations! Published in 2019 at "Neurological Research"
DOI: 10.1080/01616412.2019.1672391
Abstract: ABSTRACT Objective: Despite the application of dexmedetomidine (DEX) as a perioperative adjuvant in local analgesia, the exact analgesic mechanism underpinning chronic neuropathic pain (CNP) awaits our elucidation. Methods: We investigated the molecular mechanisms of the… read more here.
Keywords: chronic neuropathic; dex; injection; neuropathic pain ... See more keywords
A Multicriteria Decision Analysis Comparing Pharmacotherapy for Chronic Neuropathic Pain, Including Cannabinoids and Cannabis-Based Medical Products.
Sign Up to like & getrecommendations! Published in 2021 at "Cannabis and cannabinoid research"
DOI: 10.1089/can.2020.0129
Abstract: Background: Pharmacological management of chronic neuropathic pain (CNP) still represents a major clinical challenge. Collective harnessing of both the scientific evidence base and clinical experience (of clinicians and patients) can play a key role in… read more here.
Keywords: pain; chronic neuropathic; neuropathic pain; decision ... See more keywords
The Effect of Transcranial Direct Current Stimulation on Chronic Neuropathic Pain in Patients with Multiple Sclerosis: Randomized Controlled Trial.
Sign Up to like & getrecommendations! Published in 2020 at "Pain medicine"
DOI: 10.1093/pm/pnaa128
Abstract: OBJECTIVE Chronic neuropathic pain is a common symptom in multiple sclerosis (MS). This randomized controlled single-blinded study investigated whether a new protocol involving five days of transcranial direct current stimulation (tDCS) with an interval period… read more here.
Keywords: chronic neuropathic; stimulation; multiple sclerosis; neuropathic pain ... See more keywords