Ponatinib after failure of second‐generation tyrosine kinase inhibitor in resistant chronic‐phase chronic myeloid leukemia
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DOI: 10.1002/ajh.26686
Abstract: Ponatinib, the only third‐generation pan‐BCR::ABL1 inhibitor with activity against all known BCR::ABL1 mutations including T315I, has demonstrated deep and durable responses in patients with chronic‐phase chronic myeloid leukemia (CP‐CML) resistant to prior second‐generation (2G) TKI… read more here.
Keywords: chronic myeloid; leukemia; generation; phase chronic ... See more keywords
Combination of dasatinib and venetoclax in newly diagnosed chronic phase chronic myeloid leukemia
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DOI: 10.1002/cncr.35317
Abstract: The dual inhibition of the BCR::ABL1 tyrosine kinase and BCL‐2 could potentially deepen the response rates of chronic myeloid leukemia in chronic phase (CML‐CP). This study evaluated the safety and efficacy of the combination of… read more here.
Keywords: chronic phase; combination dasatinib; chronic myeloid; dasatinib venetoclax ... See more keywords
Results of ponatinib as frontline therapy for chronic myeloid leukemia in chronic phase
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DOI: 10.1002/cncr.35384
Abstract: Ponatinib is a third‐generation BCR::ABL1 tyrosine kinase inhibitor (TKI) with robust activity in Philadelphia chromosome–positive leukemias. Herein, we report the long‐term follow‐up of the phase 2 trial of ponatinib in chronic myeloid leukemia in chronic… read more here.
Keywords: chronic phase; leukemia chronic; chronic myeloid; phase ... See more keywords
Ponatinib as second-line treatment in chronic phase chronic myeloid leukemia patients in real-life practice
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DOI: 10.1007/s00277-018-3337-2
Abstract: Scarce information is available on the use of ponatinib as second-line treatment in chronic phase chronic myeloid leukemia (CP-CML) patients resistant and/or intolerant to prior tyrosine kinase inhibitor (TKI) therapy. We collected data from 29… read more here.
Keywords: line; chronic phase; treatment; line treatment ... See more keywords
Intracranial granulocytic sarcoma as the first presentation of chronic myeloid leukemia in chronic phase
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DOI: 10.1007/s11060-017-2541-6
Abstract: metamyelocytes and a few eosinophilic cells. Immunohistochemistry (IHC) showed that the tumor was strongly positive for leukocyte common antigen CD45 and pan myeloid marker CD15. Only occasional myeloblasts expressed CD117 (Fig. 1). This demonstrates that… read more here.
Keywords: phase; granulocytic sarcoma; chronic phase; myeloid leukemia ... See more keywords
LncRNA CCAT2 expression at diagnosis predicts imatinib response in chronic phase chronic myeloid leukemia patients.
Sign Up to like & getrecommendations! Published in 2022 at "Leukemia research"
DOI: 10.1016/j.leukres.2022.106838
Abstract: Long noncoding RNAs (lncRNAs) are identified as key players in the initiation, development, and prognosis of chronic myeloid leukemia (CML). Some lncRNAs are expected to serve as diagnostic biomarkers, predictors of clinical outcomes and therapeutic… read more here.
Keywords: expression; ccat2; response; chronic phase ... See more keywords
THE EARLY EVALUATION OF HEART RATE VARIATION AFTER CATHETER ABLATION PREDICTS THE RECURRENCE ON CHRONIC PHASE IN PATIENTS WITH ATRIAL FIBRILLATION
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(18)30923-9
Abstract: The heart rate variation (HRV) modified by catheter ablation (CA) procedure might impact the chronic phase recurrence in patients with atrial fibrillation (AF). We retrospectively accessed continuous 209 patients (77 females, age: 68.1±8.0, 88 with… read more here.
Keywords: atrial fibrillation; rate variation; chronic phase; catheter ablation ... See more keywords
Serum erythropoietin levels in essential thrombocythemia: phenotypic and prognostic correlates
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DOI: 10.1038/s41408-018-0157-5
Abstract: Serum erythropoietin (EPO) level below the normal reference range is widely accepted as a minor diagnostic criterion for polycythemia vera (PV) and has retained its value in the revised 2016 World Health Organization (WHO) classification… read more here.
Keywords: chronic phase; levels essential; epo; serum erythropoietin ... See more keywords
The effects of socioeconomic and geographic factors on chronic phase long-term survival after stroke in South Korea
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DOI: 10.1038/s41598-022-08025-2
Abstract: The stroke incidence has increased rapidly in South Korea, calling for a national-wide system for long-term stroke management. We investigated the effects of socioeconomic status (SES) and geographic factors on chronic phase survival after stroke.… read more here.
Keywords: survival; chronic phase; geographic factors; factors chronic ... See more keywords
A nomogram for predicting T315I-free survival in chronic phase chronic myeloid leukemia patients: a multicenter retrospective study
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DOI: 10.1038/s41598-025-89851-y
Abstract: The T315I mutation poses a significant threat to patients with chronic phase chronic myeloid leukemia (CP-CML). This study aimed to establish a nomogram to predict the risk of T315I mutation in CP-CML patients. The training… read more here.
Keywords: chronic phase; phase chronic; t315i free; free survival ... See more keywords
Effects of computer-based cognitive rehabilitation on working memory in patients with acquired brain injury in the chronic phase, a pilot-study
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DOI: 10.1080/02699052.2022.2034965
Abstract: ABSTRACT Background Working memory impairment is common in patients in the chronic phase after acquired brain injury (ABI), and there is a need to develop efficacious rehabilitation methods. This trial explored the effects of two… read more here.
Keywords: working memory; support; brain injury; memory ... See more keywords