Macrophage Depletion Improves Chronic Rejection in Rats With Allograft Heart Transplantation.
Sign Up to like & getrecommendations! Published in 2020 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2019.12.037
Abstract: BACKGROUND Macrophages may be important in chronic rejection after organ transplantation. This study aimed to investigate the possibility of depleting macrophages for a certain amount of time to alleviate chronic rejection in a heart transplant… read more here.
Keywords: macrophage depletion; chronic rejection; transplantation; expression ... See more keywords
Effects of serum from mismatched patients with solid organ transplantation on the activation of microvascular cultures isolated from adipose tissues.
Sign Up to like & getrecommendations! Published in 2021 at "Transplant immunology"
DOI: 10.1016/j.trim.2021.101462
Abstract: BACKGROUND Aggregating the human leukocyte antigen (HLA) Class I antigens on the endothelial membrane has been known to elicit an activation, an underlying mechanism of chronic rejection in organ transplant recipients. The current study aims… read more here.
Keywords: rejection; adipose tissues; transplantation; microvascular cultures ... See more keywords
Donor Specific Antibodies in Intestinal Transplant Recipients from two UK Centres May be Associated with more Severe Acute Rejection but Do not Impact Upon Chronic Rejection or Mortality
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation"
DOI: 10.1097/01.tp.0000521374.46349.1c
Abstract: Introduction: Donor specific antibodies (DSA) are implicated in poor renal transplant outcome, however their impact in intestinal transplantation (ITx) is not fully understood. DSA data is collected in all UK centres, but has not yet… read more here.
Keywords: acute rejection; dsa; rejection; mortality ... See more keywords
Prevention of Ischemia-Reperfusion Injury and Chronic Rejection in a Porcine Vascularized Composite Allotransplantation Model
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/01.tp.0000543670.93080.cc
Abstract: Aim Modern body armor, rapid evacuation, and advanced combat casualty care have improved survival after catastrophic extremity and maxillofacial trauma. Restoration using vascularized composite allotransplantation (VCA) is superior to conventional reconstruction in such injuries but… read more here.
Keywords: allotransplantation; porcine; model; composite allotransplantation ... See more keywords
The intragraft microenvironment as a central determinant of chronic rejection or local immunoregulation/tolerance
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Organ Transplantation"
DOI: 10.1097/mot.0000000000000373
Abstract: Purpose of review Chronic rejection is associated with persistent mononuclear cell recruitment, endothelial activation and proliferation, local tissue hypoxia and related biology that enhance effector immune responses. In contrast, the tumor microenvironment elicits signals/factors that… read more here.
Keywords: immunoregulation; tolerance; rejection; chronic rejection ... See more keywords
Chronic Rejection After Kidney Transplantation
Sign Up to like & getrecommendations! Published in 2024 at "Transplantation"
DOI: 10.1097/tp.0000000000005187
Abstract: In kidney transplantation, ongoing alloimmune processes—commonly triggered by HLA incompatibilities—can trigger chronic transplant rejection, affecting the microcirculation and the tubulointerstitium. Continuous inflammation may lead to progressive, irreversible graft injury, culminating in graft dysfunction and accelerated… read more here.
Keywords: kidney transplantation; rejection; transplantation; transplantation chronic ... See more keywords
Clinical Manifestation, Mechanisms, and Potential Targets of Intervention for Chronic Rejection in Vascularized Composite Allotransplantation.
Sign Up to like & getrecommendations! Published in 2025 at "Transplantation"
DOI: 10.1097/tp.0000000000005450
Abstract: As the field of vascularized composite allograft (VCA) has matured, chronic rejection (CR) has emerged as the major cause of late graft loss, albeit occurring at a lower frequency than in many solid organ transplants.… read more here.
Keywords: manifestation mechanisms; mechanisms potential; clinical manifestation; vascularized composite ... See more keywords
Identifying Risk Factors for Graft Failure due to Chronic Rejection
Sign Up to like & getrecommendations! Published in 2025 at "Pediatric Transplantation"
DOI: 10.1111/petr.70043
Abstract: Chronic rejection forms the leading cause of late graft loss in pediatric kidney transplant recipients. Despite improvement in short‐term graft outcomes, chronic rejection impedes comparable progress in long‐term graft outcomes. read more here.
Keywords: rejection; pediatric kidney; identifying risk; risk factors ... See more keywords
Zbtb7a induction in alveolar macrophages is implicated in anti-HLA–mediated lung allograft rejection
Sign Up to like & getrecommendations! Published in 2017 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aal1243
Abstract: Zbtb7a in alveolar macrophages influences early inflammation and autoimmunity in antibody-mediated rejection of transplanted lungs. Curbing culprits of chronic rejection De novo donor-specific antibodies generated after organ transplantation can lead to chronic rejection, and Nayak… read more here.
Keywords: alveolar macrophages; rejection; chronic rejection; induction ... See more keywords
Single-cell transcriptome mapping identifies a local, innate B cell population driving chronic rejection after lung transplantation
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.156648
Abstract: Bronchiolitis obliterans syndrome (BOS) is the main reason for poor outcomes after lung transplantation (LTx). We and others have recently identified B cells as major contributors to BOS after LTx. The extent of B cell… read more here.
Keywords: lung transplantation; cell; innate cell; chronic rejection ... See more keywords
Prevention of chronic rejection after lung transplantation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2017.11.85
Abstract: Long-term survival after lung transplantation (LTx) is limited by chronic rejection (CR). Therapeutic strategies for CR have been largely unsuccessful, making prevention of CR an important and challenging therapeutic approach. In the current review, we… read more here.
Keywords: prevention; chronic rejection; lung transplantation;