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Chronic Sildenafil Therapy in the ZSF1 Obese Rat Model of Metabolic Syndrome and Heart Failure With Preserved Ejection Fraction

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Published in 2021 at "Journal of Cardiovascular Pharmacology and Therapeutics"

DOI: 10.1177/10742484211034253

Abstract: Although decreased protein kinase G (PKG) activity was proposed as potential therapeutic target in heart failure with preserved ejection fraction (HFpEF), randomized clinical trials (RCTs) with type-5 phosphodiesterase inhibitors (PDE5i) showed neutral results. Whether specific… read more here.

Keywords: ejection fraction; sildenafil therapy; chronic sildenafil; preserved ejection ... See more keywords