The Non‐Peptide Vasopressin V1b Receptor Antagonist, SSR149415, Ameliorates Spermatogenesis Function in a Mouse Model of Chronic Social Defeat Stress
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DOI: 10.1002/jcb.26040
Abstract: To determine the effects of SSR149415 on testis and spermatogenesis in male mice subjected to chronic social defeat stress, C57BL/6 male mice were divided into two groups: Control and Stress. Then Stress group was subdivided… read more here.
Keywords: social defeat; defeat stress; stress; chronic social ... See more keywords
Sex‐specific behavioral, neurobiological, and cardiovascular responses to chronic social stress in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25115
Abstract: Psychosocial stress promotes and links mood and cardiovascular disorders in a sex‐specific manner. However, findings in animal models are equivocal, in some cases opposing human dimorphisms. We examined central nervous system (CNS), behavioral, endocrine, cardiac,… read more here.
Keywords: stress; chronic social; social stress; sex specific ... See more keywords
Lack of dopamine D1 receptors in the antidepressant actions of (R)-ketamine in a chronic social defeat stress model
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DOI: 10.1007/s00406-019-01012-1
Abstract: It is reported that dopamine D 1 receptors in the medial prefrontal cortex play a role in the antidepressant actions of ( R,S )-ketamine. However, its role in the antidepressant actions of ( R )-ketamine,… read more here.
Keywords: social defeat; antidepressant actions; dopamine receptors; defeat stress ... See more keywords
Computational Analysis of Multidimensional Behavioral Alterations After Chronic Social Defeat Stress
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DOI: 10.1016/j.biopsych.2020.10.010
Abstract: BACKGROUND The study of depression in humans depends on animal models that attempt to mimic specific features of the human syndrome. Most studies focus on one or a few behavioral domains, with time and practical… read more here.
Keywords: social defeat; analysis; defeat stress; behavioral alterations ... See more keywords
Hippocampal overexpression of chordin protects against the chronic social defeat stress-induced depressive-like effects in mice
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2020.02.010
Abstract: Depression is a serious and worldwide neuropsychiatric disesase, and developing novel antidepressant targets beyond the monoaminergic systems is now popular and necessary. Bone morphogenetic protein (BMP) signals modulate numerous developmental, physiological, and homeostatic processes. The… read more here.
Keywords: induced depressive; chordin; social defeat; defeat stress ... See more keywords
Hierarchical Status Predicts Behavioral Vulnerability and Nucleus Accumbens Metabolic Profile Following Chronic Social Defeat Stress
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DOI: 10.1016/j.cub.2017.06.027
Abstract: Extensive data highlight the existence of major differences in individuals' susceptibility to stress [1-4]. While genetic factors [5, 6] and exposure to early life stress [7, 8] are key components for such neurobehavioral diversity, intriguing… read more here.
Keywords: status; csds; vulnerability; chronic social ... See more keywords
Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation.
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DOI: 10.1016/j.lfs.2020.117669
Abstract: Chronic social defeat stress (CSDS) is an ethologically relevant psychosocial stress animal model and has been widely used in depression studies. Ginsenoside Rg1 (Rg1) is the major active ingredients of ginseng with low toxicity and… read more here.
Keywords: social defeat; rg1; defeat stress; depressive like ... See more keywords
Lateral hypothalamus orexinergic inputs to lateral habenula modulate maladaptation after social defeat stress
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2021.100298
Abstract: Social stress, a common stressor, causes multiple forms of physical and mental dysfunction. Prolonged exposure to social stress is associated with a higher risk of psychological disorders, including anxiety disorders and major depressive disorder (MDD).… read more here.
Keywords: social defeat; chronic social; lateral habenula; defeat stress ... See more keywords
The susceptibility to chronic social defeat stress is related to low hippocampal extrasynaptic NMDA receptor function
Sign Up to like & getrecommendations! Published in 2019 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-019-0325-8
Abstract: N-methyl-d-aspartate receptors (NMDARs) have been highly implicated in the pathogenesis and treatment of depression. While NMDARs can be found inside and outside glutamate synapses, it remains unclear if NMDARs at synaptic (sNMDAR) and extrasynaptic locations… read more here.
Keywords: social defeat; exnmdar function; low hippocampal; defeat stress ... See more keywords
Amygdala dynorphin/κ opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress.
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DOI: 10.1038/s41401-021-00677-6
Abstract: Major depression disorder is a severe and recurrent neuropsychological disorder characterized by lowered mood and social activity and cognitive impairment. Owing to unclear molecular mechanisms of depression, limited interventions are available in clinic. In this… read more here.
Keywords: social defeat; opioid receptor; chronic social; defeat stress ... See more keywords
Chronic social isolation signals starvation and reduces sleep in Drosophila.
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DOI: 10.1038/s41586-021-03837-0
Abstract: Social isolation and loneliness have potent effects on public health1-4. Research in social psychology suggests that compromised sleep quality is a key factor that links persistent loneliness to adverse health conditions5,6. Although experimental manipulations have… read more here.
Keywords: social isolation; reduces sleep; signals starvation; isolation ... See more keywords