Sickle-Cell Disease and Stroke: Quality of Life of Patients in a Chronic Transfusion Regimen from the Caregivers' Perspective.
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric hematology and oncology"
DOI: 10.1080/08880018.2022.2148030
Abstract: Strokes affect up to 10% of children with sickle-cell disease (SCD). The most commonly used strategy to prevent a first-time stroke or its recurrence is to perform periodic red blood cell transfusions. This article aims… read more here.
Keywords: cell; chronic transfusion; cell disease; quality life ... See more keywords
Personalizing transfusion in sickle cell disease: where is the canary in the mine?
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DOI: 10.1111/trf.15453
Abstract: R ed blood cell (RBC) transfusion is the cornerstone of therapy for sickle cell disease (SCD). The genetic mutation in SCD results in the production of hemoglobin (Hb) S. HbS polymerizes when deoxygenated and deforms… read more here.
Keywords: transfusion; chronic transfusion; transfusion therapy; sickle cell ... See more keywords
Adding hydroxyurea to chronic transfusion therapy for sickle cell anemia reduces transfusion burden
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DOI: 10.1111/trf.18073
Abstract: Chronic red blood cell (RBC) transfusion is an established therapy to prevent stroke in patients with sickle cell anemia (SCA). It is unclear if adding daily hydroxyurea treatment to chronic transfusion is beneficial. read more here.
Keywords: therapy; cell anemia; cell; chronic transfusion ... See more keywords
Impact of Universal Irradiation on Chronic Transfusion for Sickle Cell Disease
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DOI: 10.1182/blood-2020-140828
Abstract: Introduction: Irradiation of blood products is necessary to prevent transfusion-associated graft-versus-host disease (TA-GVHD) for patients at risk of this fatal transfusion complication. Despite the implementation of protocols to identify patients at risk of TA-GVHD, missed… read more here.
Keywords: universal irradiation; irradiation; policy; time ... See more keywords
Cerebral hemodynamic response to chronic transfusion is associated with cerebral vasculopathy in sickle cell anemia
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DOI: 10.1182/blood-2025-531
Abstract: Background Diffuse correlation spectroscopy (DCS) is a novel, non-invasive optical technique that measures an index of regional microvascular cerebral blood flow (CBF). Previously, we used DCS to demonstrate that transfusion significantly decreases CBF in SCA… read more here.
Keywords: time; response; cbf; vasculopathy ... See more keywords