Antidepressant‐like effect of flaxseed in rats exposed to chronic unpredictable stress
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DOI: 10.1002/brb3.1626
Abstract: Depression is a serious mental illness. However, a significant proportion of patients with depression fail to achieve remission with antidepressant therapies. This study was conducted to explore the antidepressant‐like effect of flaxseed oil and flour… read more here.
Keywords: unpredictable stress; chronic unpredictable; like effect; effect flaxseed ... See more keywords
Inhibition of Connexin 36 attenuates HMGB1‐mediated depressive‐like behaviors induced by chronic unpredictable mild stress
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2470
Abstract: High mobility group box 1 (HMGB1) released by neurons and microglia was demonstrated to be an important mediator in depressive‐like behaviors induced by chronic unpredictable mild stress (CUMS), which could lead to the imbalance of… read more here.
Keywords: like behaviors; chronic unpredictable; behaviors induced; induced chronic ... See more keywords
A behavioral and molecular study; ameliorated anxiety‐like behavior and cognitive dysfunction in a rat model of chronic unpredictable stress treated with oregano extract
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2727
Abstract: Chronic stress is considered a severe risk factor leading to various disorders, including anxiety and cognitive decline. The present study aimed to investigate the effects of Origanum vulgare (oregano) extract on improving anxiety‐like behavior and… read more here.
Keywords: stress; anxiety like; oregano extract; chronic unpredictable ... See more keywords
Adolescent chronic unpredictable stress causes a bias in goal-directed behavior and distinctively changes the expression of NMDA and dopamine receptors in the dorsomedial and dorsolateral striatum in male rats.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental psychobiology"
DOI: 10.1002/dev.22235
Abstract: The distinct preferences between goal-directed and habit-directed behaviors involve numerous neurodegenerative and psychiatric disorders. Chronic stress during adulthood biases behavior toward habit-oriented strategies. However, it remains to be studied how adolescence, as a stage in… read more here.
Keywords: stress; goal directed; striatum; chronic unpredictable ... See more keywords
Reduced growth capacity of preimplantation mouse embryos in chronic unpredictable stress model
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DOI: 10.1002/mrd.23439
Abstract: Psychological stress can affect female reproduction by deteriorating oocyte quality, but the molecular mechanism is unclear. In this study, we used the chronic unpredictable stress model to study the effect of psychological stress on mouse… read more here.
Keywords: unpredictable stress; chronic unpredictable; stress; stress model ... See more keywords
Paeoniflorin attenuates impairment of spatial learning and hippocampal long-term potentiation in mice subjected to chronic unpredictable mild stress
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05257-5
Abstract: Rationale and objectivePaeoniflorin has been reported to exhibit antidepressant-like effects in several animal model depression; and it also exerts a neuroprotective effect. In the present study, we investigated the effects of paeoniflorin administration on depression-like… read more here.
Keywords: subjected chronic; paeoniflorin; chronic unpredictable; mice subjected ... See more keywords
Rapid and sustained antidepressant effects of resolvin D1 and D2 in a chronic unpredictable stress model
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.06.010
Abstract: Resolvin D1 (RvD1) and D2 (RvD2) are lipid mediators that are derived from docosahexaenoic acid. We recently demonstrated that intracerebroventricular (i.c.v.) infusions of RvD1 or RvD2 attenuate lipopolysaccharide-induced depression-like behaviors via mammalian target of rapamycin… read more here.
Keywords: rapid sustained; unpredictable stress; chronic unpredictable; rvd1 rvd2 ... See more keywords
Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.112053
Abstract: Accumulating evidence shows that stressful events evoke molecular alterations in the brain, considered a pathology in major depressive disorder (MDD). However, the abnormalities of neurotransmissions as well as intracellular signaling pathways affected by chronic stress… read more here.
Keywords: chronic unpredictable; stress; coupled dopaminergic; unpredictable mild ... See more keywords
Ginsenoside 20(S)-protopanaxadiol attenuates depressive-like behaviour and neuroinflammation in chronic unpredictable mild stress-induced depressive rats
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.112710
Abstract: 20 (S)-protopanaxadiol (PPD) possesses a variety of biological activities, including antioxidant, antifatigue and anti-inflammatory properties. This study was aimed to investigate the antidepressant-like effects of PPD and potential mechanisms in rats exposed to chronic unpredictable… read more here.
Keywords: chronic unpredictable; like behaviour; depressive like; unpredictable mild ... See more keywords
Electroacupuncture alleviated the depression-like behavior by regulating FGF2 and astrocytes in the hippocampus of rats with chronic unpredictable mild stress
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.01.005
Abstract: Studies have shown that basic fibroblast growth factor (FGF2) is a neurotrophic factor associated with depression. Electroacupuncture (EA) has been shown to be an effective treatment for depression. In the current study, we observed the… read more here.
Keywords: depression; fgf2 astrocytes; chronic unpredictable; group ... See more keywords
Dehydrocorydaline induced antidepressant-like effect in a chronic unpredictable mild stress mouse model via inhibiting uptake-2 monoamine transporters.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172725
Abstract: Dehydrocorydaline, is an active alkaloid compound in Corydalis yanhusuo W. T. Wang. We found dehydrocorydaline induced antidepressant-like effects in a chronic unpredictable mild stress mouse model, but the exact mechanisms have not been addressed. We… read more here.
Keywords: chronic unpredictable; dehydrocorydaline; effect; unpredictable mild ... See more keywords