Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13113-5
Abstract: Current doctrine is that microvascular inflammation (MVI) triggered by a transplant -recipient antibody response against alloantigens (antibody-mediated rejection) is the main cause of graft failure. Here, we show that histological lesions are not mediated by… read more here.
Keywords: chronic vascular; graft; rejection; vascular rejection ... See more keywords
Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells
Sign Up to like & getrecommendations! Published in 2023 at "Science Signaling"
DOI: 10.1126/scisignal.abo3406
Abstract: The zinc finger protein ZFYVE21 is involved in immune signaling. Using humanized mouse models, primary human cells, and patient samples, we identified a T cell–autonomous role for ZFYVE21 in promoting chronic vascular inflammation associated with… read more here.
Keywords: inflammation; vascular inflammation; chronic vascular; nlrp3 inflammasomes ... See more keywords
Endothelial Senescence and the Chronic Vascular Diseases: Challenges and Therapeutic Opportunities in Atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12020215
Abstract: Atherosclerosis is probably one of the paradigms of disease linked to aging. Underlying the physiopathology of atherosclerosis are cellular senescence, oxidative stress, and inflammation. These factors are increased in the elderly and from chronic disease… read more here.
Keywords: diseases challenges; chronic vascular; senescence; endothelial senescence ... See more keywords