Diagnosis, Prognosis, and Drug Target Discovery for Chronic Widespread Pain: A Large Proteogenomic Study.
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DOI: 10.1002/advs.202507691
Abstract: Chronic widespread pain (CWP) remains challenging due to its heterogeneous causes and complex mechanisms. A total of 2920 plasma proteins are analyzed from 29,254 UK Biobank participants. A total of 256 proteins are identified as… read more here.
Keywords: diagnosis prognosis; widespread pain; pain; drug ... See more keywords
Female sexual pain: Epidemiology and genetic overlap with chronic widespread pain
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DOI: 10.1002/ejp.1042
Abstract: Increased tender spots and lowered general pain thresholds have been observed in patients with dyspareunia. Based on this, the aim of the study was to compare the co‐occurrence of female sexual pain across various pain… read more here.
Keywords: female sexual; chronic widespread; sexual pain; epidemiology ... See more keywords
Differences in long‐term physical activity trajectories among individuals with chronic widespread pain: A secondary analysis of a randomized controlled trial
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DOI: 10.1002/ejp.1410
Abstract: Little is known about long‐term physical activity (PA) maintenance in those with chronic widespread pain (CWP) following an exercise intervention. This study examined PA over time to identify the existence and characteristics of subgroups following… read more here.
Keywords: term physical; chronic widespread; long term; physical activity ... See more keywords
[Definition, diagnostics and therapy of chronic widespread pain and the (so-called) fibromyalgia syndrome in children and adolescents : Updated guidelines 2017].
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DOI: 10.1007/s00482-017-0208-z
Abstract: BACKGROUND The regular update of the guidelines on fibromyalgia syndrome, AWMF number 145/004, was scheduled for April 2017. METHODS The guidelines were developed by 13 scientific societies and 2 patient self-help organizations coordinated by the… read more here.
Keywords: pain called; fibromyalgia syndrome; chronic widespread; children adolescents ... See more keywords
Ovarian Hormone-dependent and Spinal ERK Activation-regulated Nociceptive Hypersensitivity in Female Rats with Acid Injection-induced Chronic Widespread Muscle Pain
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DOI: 10.1038/s41598-019-39472-z
Abstract: Symptoms of chronic widespread muscle pain (CWP) meet most of the diagnostic criteria for fibromyalgia syndrome, which is prevalent in females. We used an acid injection-induced muscle pain (AIMP) model to mimic CWP. After female… read more here.
Keywords: widespread muscle; chronic widespread; muscle; hypersensitivity ... See more keywords
Phenotypic characteristics of patients with chronic widespread pain and fibromyalgia: a cross-sectional cluster analysis
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DOI: 10.1080/03009742.2023.2297514
Abstract: Objective This study aimed to explore whether phenotypic characteristics of patients with chronic widespread pain (CWP) and fibromyalgia (FM) can be aggregated into definable clusters that may help to tailor treatments. Method Baseline variables (sex,… read more here.
Keywords: cluster; patients chronic; characteristics patients; phenotypic characteristics ... See more keywords
Factors promoting improvements in symptoms and health in women with fibromyalgia and chronic widespread pain: a qualitative interview study.
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DOI: 10.1080/09638288.2023.2218655
Abstract: PURPOSE To describe experiences of improvement among women with chronic widespread pain (CWP). MATERIALS AND METHODS Recruitment was made from a cohort of women with CWP who participated in a 10- to 12-year follow-up study… read more here.
Keywords: improvement; health; chronic widespread; widespread pain ... See more keywords
Cognitive decline and dementia in chronic widespread pain: A longitudinal population-based study.
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DOI: 10.1097/aln.0000000000005731
Abstract: BACKGROUND Despite preliminary research suggesting an impact of chronic pain on cognition, the direct effects of chronic widespread pain (CWP) on cognition and its underlying mechanisms remain unclear. This study aims to investigate the effects… read more here.
Keywords: dementia; widespread pain; pain; chronic widespread ... See more keywords
Genome-wide methylation analysis of a large population sample shows neurological pathways involvement in chronic widespread musculoskeletal pain
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DOI: 10.1097/j.pain.0000000000000880
Abstract: Abstract Chronic widespread musculoskeletal pain (CWP), has a considerable heritable component, which remains to be explained. Epigenetic factors may contribute to and account for some of the heritability estimate. We analysed epigenome-wide methylation using MeDIPseq… read more here.
Keywords: methylation; musculoskeletal pain; chronic widespread; widespread musculoskeletal ... See more keywords
The relationship between regional pain with or without neuropathic symptoms and chronic widespread pain.
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DOI: 10.1097/j.pain.0000000000001568
Abstract: This study was performed to test whether the risk of developing chronic widespread pain (CWP) in those with regional pain was augmented in those with symptoms of neuropathic pain (NP). Persons free of CWP completed… read more here.
Keywords: chronic widespread; widespread pain; cwp; pain relationship ... See more keywords
Chronic widespread musculoskeletal pain shares a highly heritable latent pathway with atherosclerosis and arterial stiffness
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DOI: 10.1097/j.pain.0000000000003486
Abstract: A common latent factor mediates chronic widespread pain (CWP), arterial stiffness, and atheromatous plaque association, explaining 65% of CWP, 26% of carotid–femoral pulse wave velocity, and 34% of plaque genetic variations. read more here.
Keywords: pain; latent; chronic widespread; arterial stiffness ... See more keywords