High-Throughput Rapid Yeast Chronological Lifespan Assay.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0868-5_18
Abstract: The budding yeast is a valuable model system for discovering molecular mechanisms underlying cellular aging. This is due to the ease of performing genetic manipulations in yeast and the vast number of evolutionarily conserved genes… read more here.
Keywords: yeast chronological; chronological lifespan; rapid yeast; throughput rapid ... See more keywords
Overexpression of a single ORF can extend chronological lifespan in yeast if retrograde signaling and stress response are stimulated
Sign Up to like & getrecommendations! Published in 2021 at "Biogerontology"
DOI: 10.1007/s10522-021-09924-z
Abstract: Systematic collections of single-gene deletions have been invaluable in uncovering determinants of lifespan in yeast. Overexpression of a single gene does not have such a clear outcome as cancellation of its function but it can… read more here.
Keywords: overexpression; retrograde signaling; overexpression single; chronological lifespan ... See more keywords
Metformin extends the chronological lifespan of fission yeast by altering energy metabolism and stress resistance capacity
Sign Up to like & getrecommendations! Published in 2023 at "FEMS Yeast Research"
DOI: 10.1093/femsyr/foad018
Abstract: Abstract The antiaging properties of metformin used for the treatment of type-2 diabetes mellitus have been studied extensively, but there is more to discover regarding underlying mechanisms. Here, we show that metformin significantly prolongs the… read more here.
Keywords: energy metabolism; chronological lifespan; metabolism stress; lifespan ... See more keywords
Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Microbiology"
DOI: 10.1111/mmi.13686
Abstract: Nutritional restrictions such as calorie restrictions are known to increase the lifespan of various organisms. Here, we found that a restriction of sulfur extended the chronological lifespan (CLS) of the fission yeast Schizosaccharomyces pombe. The… read more here.
Keywords: restriction; ecl1 family; sulfur restriction; chronological lifespan ... See more keywords
Caloric Restriction-Induced Extension of Chronological Lifespan Requires Intact Respiration in Budding Yeast
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DOI: 10.14348/molcells.2017.2279
Abstract: Caloric restriction (CR) has been shown to extend lifespan and prevent cellular senescence in various species ranging from yeast to humans. Many effects of CR may contribute to extend lifespan. Specifically, CR prevents oxidative damage… read more here.
Keywords: caloric restriction; chronological lifespan; extension; respiration ... See more keywords
Diverse conditions support near-zero growth in yeast: Implications for the study of cell lifespan
Sign Up to like & getrecommendations! Published in 2019 at "Microbial Cell"
DOI: 10.15698/mic2019.09.690
Abstract: Baker's yeast has a finite lifespan and ages in two ways: a mother cell can only divide so many times (its replicative lifespan), and a non-dividing cell can only live so long (its chronological lifespan).… read more here.
Keywords: yeast cultured; lifespan; chronological lifespan; diverse conditions ... See more keywords
Altered Expression of Mitochondrial NAD+ Carriers Influences Yeast Chronological Lifespan by Modulating Cytosolic and Mitochondrial Metabolism
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00676
Abstract: Nicotinamide adenine dinucleotide (NAD+) represents an essential cofactor in sustaining cellular bioenergetics and maintaining cellular fitness, and has emerged as a therapeutic target to counteract aging and age-related diseases. Besides NAD+ involvement in multiple redox… read more here.
Keywords: mitochondrial nad; metabolism; nad carriers; nad ... See more keywords