A randomized phase II trial of induction chemotherapy followed by cisplatin chronotherapy versus constant rate delivery combined with radiotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Chronobiology International"
DOI: 10.1080/07420528.2017.1397684
Abstract: ABSTRACT Chronotherapy is no longer a novel concept in cancer treatment after approximately 20 years of development. Many clinical trials have provided strong supporting evidence that chronomodulated treatment yields better results than a traditional dosage… read more here.
Keywords: chronotherapy; infusion; radiotherapy; group ... See more keywords
The effect of chronotherapy on delirium in critical care – a systematic review
Sign Up to like & getrecommendations! Published in 2018 at "Nursing in Critical Care"
DOI: 10.1111/nicc.12300
Abstract: BACKGROUND Delirium is highly prevalent within critical care and is linked to adverse clinical outcomes, increased mortality and impaired quality of life. Development of delirium is thought to be caused by multiple risk factors, including… read more here.
Keywords: chronotherapy; research; delirium critical; care ... See more keywords
The Kinetics and (Dys)kinetics of Cancer Chronotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-3799
Abstract: Circadian rhythms are the daily cycles that time almost all aspects of physiology, but treatments of the clock or by the clock are rarely tested in the clinic. We develop a framework for identifying interventions… read more here.
Keywords: chronotherapy; kinetics cancer; dys kinetics; cancer chronotherapy ... See more keywords
Impact of Chronotherapy on 6-Mercaptopurine Metabolites in Inflammatory Bowel Disease: A Pilot Crossover Trial
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Gastroenterology"
DOI: 10.14309/ctg.0000000000000549
Abstract: INTRODUCTION: Chronotherapy is the timing of medication according to biological rhythms of the host to optimize drug efficacy and minimize toxicity. Efficacy and myelosuppression of azathioprine/6-mercaptopurine (AZA/6-MP) are correlated with the metabolite 6-thioguanine, while the… read more here.
Keywords: chronotherapy; inflammatory bowel; crossover trial; bowel disease ... See more keywords
Chronotherapy: Circadian Rhythms and Their Influence in Cancer Therapy
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DOI: 10.3390/cancers14205071
Abstract: Simple Summary Living organisms present rhythmic fluctuations every 24 h in their behavior and metabolism to anticipate changes in the environment. These fluctuations are controlled by a very complex molecular mechanism, the circadian clock, that… read more here.
Keywords: rhythms; chronotherapy; therapy; circadian rhythms ... See more keywords
Personalization of Cancer Treatment: Exploring the Role of Chronotherapy in Immune Checkpoint Inhibitor Efficacy
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DOI: 10.3390/cancers17050732
Abstract: Simple Summary Immune checkpoint inhibitor (ICI) therapy for cancer is promising but often results in adverse side effects and is not consistently effective. Emerging research suggests that the efficacy of ICIs may be improved by… read more here.
Keywords: immune checkpoint; checkpoint inhibitor; chronotherapy; cancer ... See more keywords
Aperiodic Optimal Chronotherapy in Simple Compartment Tumour Growth Models Under Circadian Drug Toxicity Conditions
Sign Up to like & getrecommendations! Published in 2024 at "Mathematics"
DOI: 10.3390/math12223516
Abstract: Cancer cells typically divide with weaker synchronisation with the circadian clock than normal cells, with the degree of decoupling increasing with tumour maturity. Chronotherapy exploits this loss of synchronisation, using drugs with circadian-clock-dependent activity and… read more here.
Keywords: tumour growth; growth models; toxicity; growth ... See more keywords